Active Immunization Against Pneumocystis Carinii with a Recombinant P. Carinii Antigen

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2006 Mar 23

PMID 16552076

Citations 28

Authors

Jesse Wells

Constantine G Haidaris

Terry W Wright

Francis Gigliotti

Affiliations

Soon will be listed here.

Abstract

Mice immunized with recombinant mouse Pneumocystis carinii antigen A12-thioredoxin fusion protein developed an antibody response that recognized P. carinii antigens, as determined by Western blotting and immunofluorescence analysis. Compared to mice immunized with thioredoxin alone, mice immunized with A12-thioredoxin had significantly reduced lung P. carinii burdens after CD4+ T-cell depletion and challenge with P. carinii.

Citing Articles

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Immunization with Pneumocystis carinii A12 antigen activates immune function against P. carinii.

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Immunotherapy against Systemic Fungal Infections Based on Monoclonal Antibodies.

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