Wolbachia- and Onchocerca Volvulus-induced Keratitis (river Blindness) is Dependent on Myeloid Differentiation Factor 88

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2006 Mar 23

PMID 16552075

Citations 17

Authors

Illona Gillette-Ferguson

Amy G Hise

Yan Sun

Eugenia Diaconu

Helen F McGarry

Mark J Taylor

Eric Pearlman

Affiliations

Soon will be listed here.

Abstract

Endosymbiotic Wolbachia bacteria that infect the filarial nematode Onchocerca volvulus were previously found to have an essential role in the pathogenesis of river blindness. The current study demonstrates that corneal inflammation induced by Wolbachia or O. volvulus antigens containing Wolbachia is completely dependent on expression of myeloid differentiation factor 88.

Citing Articles

The role of helminths in the development of non-communicable diseases.

Wu Y, Duffey M, Alex S, Suarez-Reyes C, Clark E, Weatherhead J Front Immunol. 2022; 13:941977.

PMID: 36119098 PMC: 9473640. DOI: 10.3389/fimmu.2022.941977.

Pathogen-Induced Epigenetic Modifications in Cancers: Implications for Prevention, Detection and Treatment of Cancers in Africa.

Djomkam Zune A, Olwal C, Tapela K, Owoicho O, Nganyewo N, Lyko F Cancers (Basel). 2021; 13(23).

PMID: 34885162 PMC: 8656768. DOI: 10.3390/cancers13236051.

Highlighting the Relevance of CD8 T Cells in Filarial Infections.

Kwarteng A, Asiedu E, Koranteng K, Opoku Asiedu S Front Immunol. 2021; 12:714052.

PMID: 34603287 PMC: 8481813. DOI: 10.3389/fimmu.2021.714052.

MyD88 contribution to ocular surface homeostasis.

Reins R, Courson J, Lema C, Redfern R PLoS One. 2017; 12(8):e0182153.

PMID: 28796783 PMC: 5552092. DOI: 10.1371/journal.pone.0182153.

Significant heterogeneity in Wolbachia copy number within and between populations of Onchocerca volvulus.

Armoo S, Doyle S, Osei-Atweneboana M, Grant W Parasit Vectors. 2017; 10(1):188.

PMID: 28420428 PMC: 5395808. DOI: 10.1186/s13071-017-2126-4.

References

Taylor M, Cross H, Bilo K . Inflammatory responses induced by the filarial nematode Brugia malayi are mediated by lipopolysaccharide-like activity from endosymbiotic Wolbachia bacteria. J Exp Med. 2000; 191(8):1429-36. PMC: 2193140. DOI: 10.1084/jem.191.8.1429. View

Johnson A, Heinzel F, Diaconu E, Sun Y, Hise A, Golenbock D . Activation of toll-like receptor (TLR)2, TLR4, and TLR9 in the mammalian cornea induces MyD88-dependent corneal inflammation. Invest Ophthalmol Vis Sci. 2005; 46(2):589-95. DOI: 10.1167/iovs.04-1077. View

Brattig N, Rathjens U, Ernst M, Geisinger F, Renz A, Tischendorf F . Lipopolysaccharide-like molecules derived from Wolbachia endobacteria of the filaria Onchocerca volvulus are candidate mediators in the sequence of inflammatory and antiinflammatory responses of human monocytes. Microbes Infect. 2000; 2(10):1147-57. DOI: 10.1016/s1286-4579(00)01269-7. View

HALL L, Diaconu E, Patel R, Pearlman E . CXC chemokine receptor 2 but not C-C chemokine receptor 1 expression is essential for neutrophil recruitment to the cornea in helminth-mediated keratitis (river blindness). J Immunol. 2001; 166(6):4035-41. DOI: 10.4049/jimmunol.166.6.4035. View

HALL L, Diaconu E, Pearlman E . A dominant role for Fc gamma receptors in antibody-dependent corneal inflammation. J Immunol. 2001; 167(2):919-25. DOI: 10.4049/jimmunol.167.2.919. View

Cross H, Haarbrink M, Egerton G, Yazdanbakhsh M, Taylor M . Severe reactions to filarial chemotherapy and release of Wolbachia endosymbionts into blood. Lancet. 2001; 358(9296):1873-5. DOI: 10.1016/S0140-6736(01)06899-4. View

Saint Andre A, Blackwell N, Hall L, Hoerauf A, Brattig N, Volkmann L . The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness. Science. 2002; 295(5561):1892-5. DOI: 10.1126/science.1068732. View

Keiser P, Reynolds S, Awadzi K, Ottesen E, Taylor M, Nutman T . Bacterial endosymbionts of Onchocerca volvulus in the pathogenesis of posttreatment reactions. J Infect Dis. 2002; 185(6):805-11. DOI: 10.1086/339344. View

Pfarr K, Fischer K, Hoerauf A . Involvement of Toll-like receptor 4 in the embryogenesis of the rodent filaria Litomosoides sigmodontis. Med Microbiol Immunol. 2003; 192(1):53-6. DOI: 10.1007/s00430-002-0159-5. View

10.

Punkosdy G, Addiss D, Lammie P . Characterization of antibody responses to Wolbachia surface protein in humans with lymphatic filariasis. Infect Immun. 2003; 71(9):5104-14. PMC: 187306. DOI: 10.1128/IAI.71.9.5104-5114.2003. View

11.

Hayashi F, Means T, Luster A . Toll-like receptors stimulate human neutrophil function. Blood. 2003; 102(7):2660-9. DOI: 10.1182/blood-2003-04-1078. View

12.

Takeda K, Akira S . TLR signaling pathways. Semin Immunol. 2004; 16(1):3-9. DOI: 10.1016/j.smim.2003.10.003. View

13.

Vogel S, Fitzgerald K, Fenton M . TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol Interv. 2004; 3(8):466-77. DOI: 10.1124/mi.3.8.466. View

14.

Wu M, Sun L, Vamathevan J, Riegler M, DeBoy R, Brownlie J . Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a streamlined genome overrun by mobile genetic elements. PLoS Biol. 2004; 2(3):E69. PMC: 368164. DOI: 10.1371/journal.pbio.0020069. View

15.

Takeda K, Akira S . Microbial recognition by Toll-like receptors. J Dermatol Sci. 2004; 34(2):73-82. DOI: 10.1016/j.jdermsci.2003.10.002. View

16.

Brattig N, Bazzocchi C, Kirschning C, Reiling N, Buttner D, Ceciliani F . The major surface protein of Wolbachia endosymbionts in filarial nematodes elicits immune responses through TLR2 and TLR4. J Immunol. 2004; 173(1):437-45. DOI: 10.4049/jimmunol.173.1.437. View

17.

McGarry H, Egerton G, Taylor M . Population dynamics of Wolbachia bacterial endosymbionts in Brugia malayi. Mol Biochem Parasitol. 2004; 135(1):57-67. DOI: 10.1016/j.molbiopara.2004.01.006. View

18.

Gillette-Ferguson I, Hise A, McGarry H, Turner J, Esposito A, Sun Y . Wolbachia-induced neutrophil activation in a mouse model of ocular onchocerciasis (river blindness). Infect Immun. 2004; 72(10):5687-92. PMC: 517527. DOI: 10.1128/IAI.72.10.5687-5692.2004. View

19.

Kozek W, Marroquin H . Intracytoplasmic bacteria in Onchocerca volvulus. Am J Trop Med Hyg. 1977; 26(4):663-78. DOI: 10.4269/ajtmh.1977.26.663. View

20.

Eckelt V, Wildenburg G, Blaxter M, Walter R . Gene structure, activity and localization of a catalase from intracellular bacteria in Onchocerca volvulus. Mol Biochem Parasitol. 1998; 96(1-2):69-81. DOI: 10.1016/s0166-6851(98)00109-1. View