A Systematic Review of LDL Apheresis in the Treatment of Cardiovascular Disease

Overview

Journal Atherosclerosis

Publisher Elsevier

Specialty Cardiology & Vascular Diseases

Date 2006 Mar 21

PMID 16546196

Citations 19

Authors

Jeff Thompsen

Paul D Thompson

Affiliations

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Abstract

LDL apheresis is an effective method of lowering low-density lipoprotein (LDL) concentration in patients with familial hypercholesterolemia (FH) who are either refractory to treatment or intolerant of medical therapy. We searched the medical literature through July 2004 using PubMed and Medline and the search terms "LDL apheresis", "cardiovascular", and "disease" to identify apheresis techniques and to evaluate their effects on cardiovascular pathophysiology and clinical outcomes. We conclude that LDL apheresis reduces cardiovascular events in hypercholesterolemic patients and may be an effective treatment for other vascular diseases including cholesterol embolic disease, focal segmental glomerular sclerosis, sudden hearing loss, and age-related macular degeneration.

Citing Articles

Long-term efficacy of lipoprotein apheresis and lomitapide in the treatment of homozygous familial hypercholesterolemia (HoFH): a cross-national retrospective survey.

DErasmo L, Gallo A, Cefalu A, Di Costanzo A, Saheb S, Giammanco A Orphanet J Rare Dis. 2021; 16(1):381.

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Genes Potentially Associated with Familial Hypercholesterolemia.

Mikhailova S, Ivanoshchuk D, Timoshchenko O, Shakhtshneider E Biomolecules. 2019; 9(12).

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Lowering Low-Density Lipoprotein Particles in Plasma Using Dextran Sulphate Co-Precipitates Procoagulant Extracellular Vesicles.

Wang J, Zhang Y, Sze S, van de Weg S, Vernooij F, Schoneveld A Int J Mol Sci. 2017; 19(1).

PMID: 29286309 PMC: 5796044. DOI: 10.3390/ijms19010094.

Single Low-Density Lipoprotein Apheresis Does Not Improve Vascular Endothelial Function in Chronically Treated Hypercholesterolemic Patients.

Ballard K, Mah E, Guo Y, Bruno R, Taylor B, Beam J Int J Vasc Med. 2016; 2016:4613202.

PMID: 26998360 PMC: 4779839. DOI: 10.1155/2016/4613202.

Clinical utility gene card for: hyperlipoproteinemia, TYPE II.

Kassner U, Wuhle-Demuth M, Missala I, Humphries S, Steinhagen-Thiessen E, Demuth I Eur J Hum Genet. 2013; 22(7).

PMID: 24253857 PMC: 4060121. DOI: 10.1038/ejhg.2013.271.