How Can We Get More Beta Cells?

Overview

Journal Curr Diab Rep

Publisher Current Science

Specialty Endocrinology

Date 2006 Mar 18

PMID 16542618

Citations 2

Authors

Akari Inada

Susan Bonner-Weir

Elena Toschi

Affiliations

Soon will be listed here.

Abstract

The need for a reliable source of functional beta cells has led to many new investigations in an effort to drive the differentiation of embryonic stem cells, of putative stem cells, or of pancreatic progenitor cells to form new beta cells. There appears to be a plasticity of pancreatic cells in vitro that may be exploited to generate the necessary beta cells. Major questions still remain: whether there are true pancreatic stem cells, what are the pancreatic progenitor cells after birth, and whether expanded beta cells themselves could serve as the source.

Citing Articles

Differentiation, reduction, and proliferation of pancreatic β-cells and their regulatory factors.

Inada A Diabetol Int. 2025; 16(1):23-29.

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Inhibition of beta cell growth and function by bone morphogenetic proteins.

Bruun C, Christensen G, Jacobsen M, Kanstrup M, Jensen P, Fjordvang H Diabetologia. 2014; 57(12):2546-54.

PMID: 25260823 DOI: 10.1007/s00125-014-3384-8.

Review of vitreous islet cryopreservation: Some practical issues and their resolution.

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