Cardioprotective Effect of Mangiferin on Isoproterenol Induced Myocardial Infarction in Rats

Overview

Journal Indian J Exp Biol

Specialty Biology

Date 2006 Mar 17

PMID 16538859

Citations 10

Authors

S Prabhu

Mallika Jainu

K E Sabitha

C S Shyamala Devi

Affiliations

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Abstract

Isoproterenol (ISPH) induced myocardial infarction was confirmed by disturbances in serum and heart tissue marker enzymes such as lactate dehydrogenase (LDH), creatine phospho kinase (CPK), aspartate transaminase (AST) and alanine transaminase (ALT), increased level of lipid peroxidation and histopathological changes in the heart of ISPH administered rats. Pretreatment with mangiferin (10 mg/100 g body weight) for 28 days was found to ameliorate the effect of ISPH-induced pathological changes, reduced the lipid peroxide formation and retained the myocardial marker enzyme activities at near normal level. The above results indicate the cardioprotective effect of mangiferin against ISPH-induced myocardial infarction in rats.

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