» Articles » PMID: 16533740

Biology of Normal and Acute Myeloid Leukemia Stem Cells

Overview
Journal Int J Hematol
Specialty Hematology
Date 2006 Mar 15
PMID 16533740
Citations 41
Authors
Affiliations
Soon will be listed here.
Abstract

The substantial understanding that has been gained over the past 5 decades of the biology of blood formation is largely due to the development of functional quantitative assays for cells at all stages of differentiation, from multipotential stem cells to mature cells. The majority of studies have involved the mouse because the ease with which repopulation studies can be carried out with this animal model allows the assay of complete lineage development from stem cells. In the past decade, advances in repopulation assays for human stem cells using xenotransplantation have greatly enhanced our understanding of human stem cell biology. Importantly, the xenotransplantation methodology has also been used to identify the cancer stem cell that initiates and sustains leukemic proliferation, providing key evidence for the cancer stem cell hypothesis. This hypothesis argues that cancer cells are functionally heterogeneous and hierarchically organized such that only specific cells are capable of sustaining tumor growth and continuously producing the cells that make up the bulk of the tumor. Recent studies have also brought into focus the importance of the intimate relationship between the stem cell (normal or leukemic) and its microenvironment. Coming into view are the molecular players involved in stem cell homing, migration, and adhesion, as well as the cellular components of the microenvironmental niche. Here we review recent studies that have begun, to elucidate the interplay between normal and leukemic human stem cells and their microenvironment.

Citing Articles

Auraptene-induced cytotoxic effects in acute myeloid leukemia cell lines.

Ghorbani M, Soukhtanloo M, Salek Farrokhi A, Hassanian S, Ghorbani F, Afshari A Med Oncol. 2023; 40(8):231.

PMID: 37432498 DOI: 10.1007/s12032-023-02088-5.


Targeted Therapeutic Approach Based on Understanding of Aberrant Molecular Pathways Leading to Leukemic Proliferation in Patients with Acute Myeloid Leukemia.

Song M, Park B, Uhm J Int J Mol Sci. 2021; 22(11).

PMID: 34071627 PMC: 8198876. DOI: 10.3390/ijms22115789.


Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice.

Saito Y, Shultz L, Ishikawa F Trends Immunol. 2020; 41(8):706-720.

PMID: 32631635 PMC: 7395895. DOI: 10.1016/j.it.2020.06.004.


Cancer stem cells in esophageal squamous cell cancer.

Wu Q, Wu Z, Bao C, Li W, He H, Sun Y Oncol Lett. 2019; 18(5):5022-5032.

PMID: 31612013 PMC: 6781610. DOI: 10.3892/ol.2019.10900.


Clonal evolution of acute myeloid leukemia from diagnosis to relapse.

Vosberg S, Greif P Genes Chromosomes Cancer. 2019; 58(12):839-849.

PMID: 31478278 PMC: 6852285. DOI: 10.1002/gcc.22806.


References
1.
Lemischka I, Jordan C . The return of clonal marking sheds new light on human hematopoietic stem cells. Nat Immunol. 2001; 2(1):11-2. DOI: 10.1038/83115. View

2.
Wang J, Dick J . Cancer stem cells: lessons from leukemia. Trends Cell Biol. 2005; 15(9):494-501. DOI: 10.1016/j.tcb.2005.07.004. View

3.
Traggiai E, Chicha L, Mazzucchelli L, Bronz L, Piffaretti J, Lanzavecchia A . Development of a human adaptive immune system in cord blood cell-transplanted mice. Science. 2004; 304(5667):104-7. DOI: 10.1126/science.1093933. View

4.
Bendall L, Daniel A, Kortlepel K, Gottlieb D . Bone marrow adherent layers inhibit apoptosis of acute myeloid leukemia cells. Exp Hematol. 1994; 22(13):1252-60. View

5.
Benveniste P, Cantin C, Hyam D, Iscove N . Hematopoietic stem cells engraft in mice with absolute efficiency. Nat Immunol. 2003; 4(7):708-13. DOI: 10.1038/ni940. View