Recently Mobilized Transposons in the Human and Chimpanzee Genomes

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 2006 Mar 15

PMID 16532396

Citations 74

Authors

Ryan E Mills

E Andrew Bennett

Rebecca C Iskow

Christopher T Luttig

Circe Tsui

W Stephen Pittard

Scott E Devine

Affiliations

Soon will be listed here.

Abstract

Transposable genetic elements are abundant in the genomes of most organisms, including humans. These endogenous mutagens can alter genes, promote genomic rearrangements, and may help to drive the speciation of organisms. In this study, we identified almost 11,000 transposon copies that are differentially present in the human and chimpanzee genomes. Most of these transposon copies were mobilized after the existence of a common ancestor of humans and chimpanzees, approximately 6 million years ago. Alu, L1, and SVA insertions accounted for >95% of the insertions in both species. Our data indicate that humans have supported higher levels of transposition than have chimpanzees during the past several million years and have amplified different transposon subfamilies. In both species, approximately 34% of the insertions were located within known genes. These insertions represent a form of species-specific genetic variation that may have contributed to the differential evolution of humans and chimpanzees. In addition to providing an initial overview of recently mobilized elements, our collections will be useful for assessing the impact of these insertions on their hosts and for studying the transposition mechanisms of these elements.

Citing Articles

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