The Nuclear Pore Complex: the Gateway to Successful Nonviral Gene Delivery

Overview

Journal Pharm Res

Specialties Pharmacology
Pharmacy

Date 2006 Mar 10

PMID 16525863

Citations 36

Authors

Marieke A E M van der Aa

Enrico Mastrobattista

Ronald S Oosting

Wim E Hennink

Gerben A Koning

Daan J A Crommelin

Affiliations

Soon will be listed here.

Abstract

One of the limiting steps in the efficiency of nonviral gene delivery is transport of genetic material across the nuclear membrane. Trafficking of nuclear proteins from the cytoplasm into the nucleus occurs via the nuclear pore complex and is mediated by nuclear localization signals and their nuclear receptors. Several strategies employing this transport mechanism have been designed and explored to improve nonviral gene delivery. In this article, we review the mechanism of nuclear import through the nuclear pore complex and the strategies used to facilitate nuclear import of exogenous DNA and improve gene expression.

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