Antidiabetic Effects of Corosolic Acid in KK-Ay Diabetic Mice

Overview

Journal Biol Pharm Bull

Specialty Biochemistry

Date 2006 Mar 2

PMID 16508174

Citations 17

Authors

Toshihiro Miura

Naoya Ueda

Koutaro Yamada

Mitsuo Fukushima

Torao Ishida

Tetsuo Kaneko

Futoshi Matsuyama

Yutaka Seino

Affiliations

Soon will be listed here.

Abstract

The antidiabetic effects of corosolic acid (CA) were investigated in KK-Ay mice, an animal model of type 2 diabetes. CA (2 mg/kg body weight) reduced the blood glucose levels of KK-Ay mice 4 h after a single oral dose. CA (2 mg/kg) reduced the blood glucose levels in KK-Ay mice 2 weeks after a single oral dose and also significantly lowered plasma insulin levels were in KK-Ay mice under similar conditions. CA-treated KK-Ay mouse blood glucose significantly decreased in an insulin tolerance test. These results support the hypothesis that CA improves glucose metabolism by reducing insulin resistance. Therefore CA may be useful for the treatment of type 2 diabetes.

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