Enhancement of Human Immunodeficiency Virus 1 Replication in Monocytes by 1,25-dihydroxycholecalciferol

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1991 Aug 1

PMID 1650477

Citations 10

Authors

P R Skolnik

B Jahn

M Z Wang

T R ROTA

M S Hirsch

S M Krane

Affiliations

Soon will be listed here.

Abstract

Human immunodeficiency virus (HIV) expression and replication are under tight regulatory control. We demonstrate that 1,25-dihydroxycholecalciferol [1,25-(OH)2D3] enhances the replication of monocyte- and lymphocyte-tropic strains of HIV-1 up to 10,000-fold in monocyte cell lines, peripheral blood monocytes, and unfractionated peripheral blood mononuclear cells. 1,25(OH)2D3 is therefore one of the most potent regulators of HIV-1 replication described to date. Precursors of 1,25(OH)2D3 enhance HIV-1 replication in proportion to their affinity for the 1,25(OH)2D3 intracellular receptor, suggesting that 1,25(OH)2D3 influences HIV-1 replication by mechanisms involving this receptor. These studies may have important implications for the design of effective therapy of HIV-1 infection.

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References

Locardi C, Petrini C, Boccoli G, Testa U, Dieffenbach C, Butto S . Increased human immunodeficiency virus (HIV) expression in chronically infected U937 cells upon in vitro differentiation by hydroxyvitamin D3: roles of interferon and tumor necrosis factor in regulation of HIV production. J Virol. 1990; 64(12):5874-82. PMC: 248750. DOI: 10.1128/JVI.64.12.5874-5882.1990. View

Scolnick E, Young H, Parks W . Biochemical and physiological mechanisms in glucocorticoid hormone induction of mouse mammary tumor virus. Virology. 1976; 69(1):148-56. DOI: 10.1016/0042-6822(76)90202-6. View

Cavard C, Zider A, Vernet M, Bennoun M, Saragosti S, Grimber G . In vivo activation by ultraviolet rays of the human immunodeficiency virus type 1 long terminal repeat. J Clin Invest. 1990; 86(4):1369-74. PMC: 296873. DOI: 10.1172/JCI114849. View

Valerie K, Delers A, BRUCK C, Thiriart C, Rosenberg H, Debouck C . Activation of human immunodeficiency virus type 1 by DNA damage in human cells. Nature. 1988; 333(6168):78-81. DOI: 10.1038/333078a0. View

Morrison N, Shine J, Fragonas J, Verkest V, McMenemy M, Eisman J . 1,25-dihydroxyvitamin D-responsive element and glucocorticoid repression in the osteocalcin gene. Science. 1989; 246(4934):1158-61. DOI: 10.1126/science.2588000. View

Cato A, Skroch P, Weinmann J, Butkeraitis P, Ponta H . DNA sequences outside the receptor-binding sites differently modulate the responsiveness of the mouse mammary tumour virus promoter to various steroid hormones. EMBO J. 1988; 7(5):1403-10. PMC: 458390. DOI: 10.1002/j.1460-2075.1988.tb02957.x. View

Griffin G, Leung K, Folks T, Kunkel S, Nabel G . Activation of HIV gene expression during monocyte differentiation by induction of NF-kappa B. Nature. 1989; 339(6219):70-3. DOI: 10.1038/339070a0. View

Skolnik P, Kosloff B, Hirsch M . Bidirectional interactions between human immunodeficiency virus type 1 and cytomegalovirus. J Infect Dis. 1988; 157(3):508-14. DOI: 10.1093/infdis/157.3.508. View

Minghetti P, Norman A . 1,25(OH)2-vitamin D3 receptors: gene regulation and genetic circuitry. FASEB J. 1988; 2(15):3043-53. DOI: 10.1096/fasebj.2.15.2847948. View

10.

Kornfeld H, Cruikshank W, Pyle S, Berman J, Center D . Lymphocyte activation by HIV-1 envelope glycoprotein. Nature. 1988; 335(6189):445-8. DOI: 10.1038/335445a0. View

11.

Gartner S, Markovits P, Markovitz D, Kaplan M, Gallo R, Popovic M . The role of mononuclear phagocytes in HTLV-III/LAV infection. Science. 1986; 233(4760):215-9. DOI: 10.1126/science.3014648. View

12.

Cordingley M, Riegel A, Hager G . Steroid-dependent interaction of transcription factors with the inducible promoter of mouse mammary tumor virus in vivo. Cell. 1987; 48(2):261-70. DOI: 10.1016/0092-8674(87)90429-6. View

13.

Rigby W . The immunobiology of vitamin D. Immunol Today. 1988; 9(2):54-8. View

14.

Stanley S, Folks T, Fauci A . Induction of expression of human immunodeficiency virus in a chronically infected promonocytic cell line by ultraviolet irradiation. AIDS Res Hum Retroviruses. 1989; 5(4):375-84. DOI: 10.1089/aid.1989.5.375. View

15.

Pauza C, Galindo J, Richman D . Human immunodeficiency virus infection of monoblastoid cells: cellular differentiation determines the pattern of virus replication. J Virol. 1988; 62(10):3558-64. PMC: 253494. DOI: 10.1128/JVI.62.10.3558-3564.1988. View

16.

Folks T, Justement J, Kinter A, Schnittman S, Orenstein J, Poli G . Characterization of a promonocyte clone chronically infected with HIV and inducible by 13-phorbol-12-myristate acetate. J Immunol. 1988; 140(4):1117-22. View

17.

Zagury D, Bernard J, Leonard R, Cheynier R, Feldman M, SARIN P . Long-term cultures of HTLV-III--infected T cells: a model of cytopathology of T-cell depletion in AIDS. Science. 1986; 231(4740):850-3. DOI: 10.1126/science.2418502. View

18.

Cloyd M, Lynn W, Ramsey K, Baron S . Inhibition of human immunodeficiency virus (HIV-1) infection by diphenylhydantoin (dilantin) implicates role of cellular calcium in virus life cycle. Virology. 1989; 173(2):581-90. DOI: 10.1016/0042-6822(89)90569-2. View

19.

Skolnik P, Kosloff B, Bechtel L, Huskins K, Flynn T, Karthas N . Absence of infectious HIV-1 in the urine of seropositive viremic subjects. J Infect Dis. 1989; 160(6):1056-60. DOI: 10.1093/infdis/160.6.1056. View

20.

Gendelman H, Orenstein J, Baca L, Weiser B, Burger H, Kalter D . The macrophage in the persistence and pathogenesis of HIV infection. AIDS. 1989; 3(8):475-95. DOI: 10.1097/00002030-198908000-00001. View