IL-4 Alpha Chain Receptor (IL-4Ralpha) Polymorphisms in Allergic Bronchopulmonary Sspergillosis

Overview

Journal Clin Mol Allergy

Publisher Biomed Central

Specialty Allergy & Immunology

Date 2006 Mar 1

PMID 16503977

Citations 12

Authors

Alan P Knutsen

Barbara Kariuki

Judy D Consolino

Manoj R Warrier

Affiliations

Soon will be listed here.

Abstract

Background: Allergic bronchopulmonary aspergillosis occurs in 7-10% of cystic fibrosis (CF) and 1-2% of asthmatic patients. HLA-DR restriction and increased sensitivity to IL-4 stimulation have been proposed as risk factors in these populations.

Objective: We examined for the presence of IL-4 receptor alpha chain (IL-4Ralpha) single nucleotide polymorphisms (SNPs) in ABPA and whether these accounted for increased sensitivity to IL-4 stimulation.

Methods: One extracellular (ile75val) and four cytoplasmic IL-4Ralpha SNPs were analyzed in 40 CF and 22 asthmatic patients and in 56 non-ABPA CF and asthmatic patients. Sensitivity to IL-4 stimulation was measured by induction of CD23 expression on B cells.

Results: IL-4Ralpha SNPs were observed in 95% of ABPA patients. The predominant IL-4Ralpha SNP was the extracellular IL-4Ralpha SNP, ile75val, observed in 80% of ABPA patients.

Conclusion: The presence of IL-4Ralpha SNPs, principally ile75val, appears to be a genetic risk for the development of ABPA.

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