The Efficacy of Tc99m Dimercaptosuccinic Acid (Tc-DMSA) Scintigraphy and Ultrasonography in Detecting Renal Scars in Children with Primary Vesicoureteral Reflux (VUR)

Overview

Journal Int Urol Nephrol

Publisher Springer

Specialty Nephrology

Date 2006 Feb 28

PMID 16502071

Citations 13

Authors

Y Temiz

T Tarcan

F F Onol

H Alpay

F Simsek

Affiliations

Soon will be listed here.

Abstract

Introduction: Pyelonephritis-induced renal scarring in children is a major predisposing factor for proteinuria, hypertension, and ultimate renal failure. The aim of this study was to investigate and compare the efficacy of Tc99m dimercaptosuccinic acid (Tc-DMSA) renal scintigraphy and renal ultrasonography (USG) in detecting renal scars in children with primary vesicoureteral reflux (VUR).

Materials And Methods: Tc-DMSA scan and USG studies were done in 62 children who were admitted to our clinic between 1997 and 2003 because of documented urinary tract infection (UTI) and diagnosed with primary VUR. Renal scarring detection rates of Tc-DMSA scan and USG were compared according to reflux grades.

Results: In the whole group, renal scars were detected by Tc-DMSA scan and USG in 55% and 38% of refluxing units, respectively. Detection rates of Tc-DMSA and USG according to reflux grades were as follows: 47% and 29 % in low-grade VUR (grades 1 and 2), 46 % and 25% in mid-grade VUR (grade 3), 76% and 65% in high-grade VUR (grades 4 and 5), respectively.

Conclusion: USG was found to be an inappropriate study in the detection of renal parenchymal scars, irrespective of the reflux grade. In this study, Tc-DMSA scan detected scars in 35% of kidneys reported to be normal on USG.

Citing Articles

Renal Cortical Imaging with Tc-99m DMSA in Children: An Institutional Review.

Hardina S, Nugrahadi T, Budiawan H, Kartamihardja A World J Nucl Med. 2024; 23(3):180-184.

PMID: 39170843 PMC: 11335390. DOI: 10.1055/s-0044-1787717.

Correlation of Renal Scarring to Urinary Tract Infections and Vesicoureteral Reflux in Children.

Aboutaleb H, Abouelgreed T, El-Hagrasi H, Eldib D, Abdelaal M, El Gohary M Adv Urol. 2022; 2022:9697931.

PMID: 35529476 PMC: 9072046. DOI: 10.1155/2022/9697931.

Diagnostic performance of contrast-enhanced ultrasound for acute pyelonephritis in children.

Jung H, Choi M, Pai K, Kim H Sci Rep. 2020; 10(1):10715.

PMID: 32612243 PMC: 7330043. DOI: 10.1038/s41598-020-67713-z.

Dimercaptosuccinic acid scintigraphy vs. ultrasound for renal parenchymal defects in children.

Marceau-Grimard M, Marion A, Cote C, Bolduc S, Dumont M, Moore K Can Urol Assoc J. 2017; 11(8):260-264.

PMID: 28798828 PMC: 5542835. DOI: 10.5489/cuaj.4257.

Dimercaptosuccinic acid scan or ultrasound in screening for vesicoureteral reflux among children with urinary tract infections.

Shaikh N, Spingarn R, Hum S Cochrane Database Syst Rev. 2016; 7:CD010657.

PMID: 27378557 PMC: 6457894. DOI: 10.1002/14651858.CD010657.pub2.

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