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Between a Rock and a Hard Place?

Overview
Journal Nat Chem Biol
Date 2006 Feb 18
PMID 16484997
Citations 84
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Abstract

Developing small-molecule inhibitors against protein-protein interaction targets is among the most difficult challenges in contemporary drug discovery. Recent developments in our understanding of this problem, and in the knowledge and tools available to address it, give cause for renewed hope, but substantial challenges remain.

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