Regioselective and Enantiospecific Rhodium-catalyzed Allylic Amination with Thymine: Synthesis of a New Conformationally Rigid Nucleoside

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2006 Feb 16

PMID 16479286

Citations 2

Authors

P Andrew Evans

Kwong Wah Lai

Hai-Ren Zhang

John C Huffman

Affiliations

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Abstract

The regioselective and enantiospecific rhodium-catalyzed allylic amination of secondary allylic carbonates with N3-benzoyl thymine in conjunction with a stereoselective free radical cyclization provides a convenient method for the construction of a new conformationally rigid nucleoside.

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