Sodium Butyrate Induces Apoptosis and Cell Cycle Arrest in Primary Effusion Lymphoma Cells Independently of Oxidative Stress and P21(CIP1/WAF1) Induction

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2006 Feb 16

PMID 16477379

Citations 7

Authors

Yi-Fen Wang

Neou-Shi Chen

Yu-Ping Chung

Lon-Huey Chang

Yee-Hsuan Chiou

Chang-Yu Chen

Affiliations

Soon will be listed here.

Abstract

Primary effusion lymphoma, a peculiar type of B cell non-Hodgkin lymphoma, preferentially develops in immunodeficient individuals and its pathogenesis is closely linked with human herpesvirus 8 (HHV-8). HHV-8 is present primarily persistence in primary effusion lymphoma cells, and the lytic cycle of HHV-8 can be induced by sodium butyrate (NaB) treatment. HHV-8 gene expression is affected by NaB in BCBL-1 cells, but the cellular response of BCBL-1 cells upon NaB treatment has not been investigated to date. Using BCBL-1 cells, a HHV-8 harboring cell line, we demonstrated that sodium butyrate could induce the reactive oxygen species generation, apoptosis and cell cycle arrest in BCBL-1 cells. The sodium butyrate-induce cell cycle arrest was associated with the decrease of Cdc2, Cdk4 and cyclin A in BCBL-1 cells without altering the protein levels of p21(CIP1/WAF1). The apoptosis induced by sodium butyrate in BCBL-1 cells was independent of oxidative stress.

Citing Articles

Short-chain fatty acids induced lung tumor cell death and increased peripheral blood CD4+ T cells in NSCLC and control patients ex vivo.

Thome C, Tausche P, Hohenberger K, Yang Z, Krammer S, Trufa D Front Immunol. 2024; 15:1328263.

PMID: 38650948 PMC: 11033355. DOI: 10.3389/fimmu.2024.1328263.

Down-Regulation of the Mammalian Target of Rapamycin (mTOR) Pathway Mediates the Effects of the Paeonol-Platinum(II) Complex in Human Thyroid Carcinoma Cells and Mouse SW1736 Tumor Xenografts.

He L, Guo S, Zhu T, Chen C, Xu K Med Sci Monit. 2020; 26:e922561.

PMID: 32594094 PMC: 7341900. DOI: 10.12659/MSM.922561.

RNA Sequencing Analysis of Molecular Basis of Sodium Butyrate-Induced Growth Inhibition on Colorectal Cancer Cell Lines.

Zhou Q, Li G, Zuo S, Zhu W, Yuan X Biomed Res Int. 2019; 2019:1427871.

PMID: 30937307 PMC: 6415300. DOI: 10.1155/2019/1427871.

Knockdown of MSI1 inhibited the cell proliferation of human osteosarcoma cells by targeting p21 and p27.

Niu J, Zhao X, Liu Q, Yang J Oncol Lett. 2017; 14(5):5271-5278.

PMID: 29113163 PMC: 5661380. DOI: 10.3892/ol.2017.6870.

Potential anti-genotoxic effect of sodium butyrate to modulate induction of DNA damage by tamoxifen citrate in rat bone marrow cells.

El-Shorbagy H Cytotechnology. 2016; 69(1):89-102.

PMID: 27905024 PMC: 5264625. DOI: 10.1007/s10616-016-0039-2.

References

Staskus K, Zhong W, GEBHARD K, Herndier B, Wang H, Renne R . Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol. 1997; 71(1):715-9. PMC: 191104. DOI: 10.1128/JVI.71.1.715-719.1997. View

Cloutier N, Gravel A, Flamand L . Multiplex detection and quantitation of latent and lytic transcripts of human herpesvirus-8 using RNase Protection Assay. J Virol Methods. 2004; 122(1):1-7. DOI: 10.1016/j.jviromet.2004.07.004. View

Boshoff C, Schulz T, Kennedy M, Graham A, Fisher C, Thomas A . Kaposi's sarcoma-associated herpesvirus infects endothelial and spindle cells. Nat Med. 1995; 1(12):1274-8. DOI: 10.1038/nm1295-1274. View

Zamzami N, Marchetti P, Castedo M, Decaudin D, Macho A, Hirsch T . Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med. 1995; 182(2):367-77. PMC: 2192111. DOI: 10.1084/jem.182.2.367. View

Inman G, Binne U, Parker G, Farrell P, Allday M . Activators of the Epstein-Barr virus lytic program concomitantly induce apoptosis, but lytic gene expression protects from cell death. J Virol. 2001; 75(5):2400-10. PMC: 114823. DOI: 10.1128/JVI.75.5.2400-2410.2001. View

Wang X, Li J, Evers B . Inhibition of proliferation, invasion and adhesion of liver cancer cells by 5-azacytidine and butyrate. Anticancer Res. 2000; 19(4B):2901-6. View

Friborg Jr J, Kong W, Hottiger M, Nabel G . p53 inhibition by the LANA protein of KSHV protects against cell death. Nature. 2000; 402(6764):889-94. DOI: 10.1038/47266. View

Patnaik A, Rowinsky E, Villalona M, Hammond L, Britten C, Siu L . A phase I study of pivaloyloxymethyl butyrate, a prodrug of the differentiating agent butyric acid, in patients with advanced solid malignancies. Clin Cancer Res. 2002; 8(7):2142-8. View

Chopin V, Toillon R, Jouy N, Le Bourhis X . P21(WAF1/CIP1) is dispensable for G1 arrest, but indispensable for apoptosis induced by sodium butyrate in MCF-7 breast cancer cells. Oncogene. 2004; 23(1):21-9. DOI: 10.1038/sj.onc.1207020. View

10.

Frenkel K, Gleichauf C . Hydrogen peroxide formation by cells treated with a tumor promoter. Free Radic Res Commun. 1991; 12-13 Pt 2:783-94. DOI: 10.3109/10715769109145860. View

11.

Cesarman E, Chang Y, Moore P, Said J, Knowles D . Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med. 1995; 332(18):1186-91. DOI: 10.1056/NEJM199505043321802. View

12.

Verschuren E, Jones N, Evan G . The cell cycle and how it is steered by Kaposi's sarcoma-associated herpesvirus cyclin. J Gen Virol. 2004; 85(Pt 6):1347-1361. DOI: 10.1099/vir.0.79812-0. View

13.

Renne R, Zhong W, Herndier B, McGrath M, Abbey N, Kedes D . Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture. Nat Med. 1996; 2(3):342-6. DOI: 10.1038/nm0396-342. View

14.

Sowa Y, Sakai T . Butyrate as a model for "gene-regulating chemoprevention and chemotherapy.". Biofactors. 2001; 12(1-4):283-7. DOI: 10.1002/biof.5520120142. View

15.

Yu Y, Black J, Goldsmith C, Browning P, Bhalla K, Offermann M . Induction of human herpesvirus-8 DNA replication and transcription by butyrate and TPA in BCBL-1 cells. J Gen Virol. 1999; 80 ( Pt 1):83-90. DOI: 10.1099/0022-1317-80-1-83. View

16.

Chang Y, Cesarman E, Pessin M, Lee F, Culpepper J, Knowles D . Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 1994; 266(5192):1865-9. DOI: 10.1126/science.7997879. View

17.

Louis M, Rosato R, Brault L, Osbild S, Battaglia E, Yang X . The histone deacetylase inhibitor sodium butyrate induces breast cancer cell apoptosis through diverse cytotoxic actions including glutathione depletion and oxidative stress. Int J Oncol. 2004; 25(6):1701-11. View

18.

Terao Y, Nishida J, Horiuchi S, Rong F, Ueoka Y, Matsuda T . Sodium butyrate induces growth arrest and senescence-like phenotypes in gynecologic cancer cells. Int J Cancer. 2001; 94(2):257-67. DOI: 10.1002/ijc.1448. View

19.

Li H, Wu X . Histone deacetylase inhibitor, Trichostatin A, activates p21WAF1/CIP1 expression through downregulation of c-myc and release of the repression of c-myc from the promoter in human cervical cancer cells. Biochem Biophys Res Commun. 2004; 324(2):860-7. DOI: 10.1016/j.bbrc.2004.09.130. View

20.

Marks P, Richon V, Breslow R, Rifkind R . Histone deacetylase inhibitors as new cancer drugs. Curr Opin Oncol. 2001; 13(6):477-83. DOI: 10.1097/00001622-200111000-00010. View