Crossroads in GDNF Therapy for Parkinson's Disease

Overview

Journal Mov Disord

Date 2006 Feb 14

PMID 16470786

Citations 51

Authors

Todd B Sherer

Brian K Fiske

Clive N Svendsen

Anthony E Lang

J William Langston

Affiliations

Soon will be listed here.

Abstract

The development of a neuroprotective or neuroregenerative therapy for Parkinson's disease (PD) would be a major therapeutic advance. Unfortunately, results from a recent controlled clinical study delivering the neurotrophic factor, glial-derived neurotrophic factor (GDNF), directly into brain did not demonstrate efficacy and safety of such a treatment. A critical review of available data suggests that there are questions that need to be answered before the future of GDNF as a therapy for PD can be determined.

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