Mouse Platelet-derived Growth Factor Receptor Alpha Gene is Deleted in W19H and Patch Mutations on Chromosome 5

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1991 Jun 1

PMID 1647018

Citations 18

Authors

E A Smith

M F Seldin

L Martinez

M L Watson

G G Choudhury

P A Lalley

J Pierce

S Aaronson

J Barker

S L Naylor

Affiliations

Soon will be listed here.

Abstract

The mouse W19H mutation is an x-ray-induced deletion of more than 2 centimorgans on chromosome 5 encompassing the white spotting mutation W (encoded by the Kit protooncogene), patch (Ph), and recessive lethal (l) loci. The platelet-derived growth factor receptor alpha gene (PDGFRA) like Kit encodes a transmembrane receptor tyrosine kinase. By using mouse-Chinese hamster somatic cell hybrids and haplotype analysis in interspecific backcross mice, mouse Pdgfra was mapped to chromosome 5 in tight linkage with Kit. Hybridization of a PDGFRA probe to DNAs from W19H/ + heterozygous mice and patch heterozygous mice, and their wild-type littermates, demonstrated deletion of Pdgfra. Pulsed-field gel electrophoresis indicated that Kit and Pdgfra are linked on a 630-kilobase Mlu I DNA fragment. Thus the W19H deletion removes at least two receptor tyrosine kinases and the results suggest Pdgfra as a candidate for the Ph locus.

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