The Plasma Alpha-synuclein Levels in Patients with Parkinson's Disease and Multiple System Atrophy

Overview

Journal J Neural Transm (Vienna)

Specialties Neurology
Physiology

Date 2006 Feb 9

PMID 16465458

Citations 100

Authors

P H Lee

G Lee

H J Park

O Y Bang

I S Joo

K Huh

Affiliations

Soon will be listed here.

Abstract

alpha-Synuclein, a synaptic protein of unknown function, is a major component of Lewy bodies and may play a role in the pathophysiological process of Parkinson's disease (PD). In this study, we measured the plasma alpha-synuclein levels in 105 patients with PD, 38 patients with multiple system atrophy (MSA), and 51 age-matched controls. The alpha-synuclein level was significantly elevated in patients with PD (79.9 +/- 4.0 pg/ml, p < 0.001) and in those with MSA (78.1 +/- 3.5 pg/ml, p = 0.019) compared with the level in controls (76.1 +/- 3.9 pg/ml). The alpha-synuclein level was higher in patients with PD than in those with MSA (79.9 +/- 4.0 vs 78.1 +/- 3.5, p = 0.016). Our study demonstrated that the alpha-synuclein level in plasma is elevated in patients with PD and MSA.

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References

Hughes A, Daniel S, Kilford L, Lees A . Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry. 1992; 55(3):181-4. PMC: 1014720. DOI: 10.1136/jnnp.55.3.181. View

HOEHN M, Yahr M . Parkinsonism: onset, progression and mortality. Neurology. 1967; 17(5):427-42. DOI: 10.1212/wnl.17.5.427. View

El-Agnaf O, Salem S, Paleologou K, Cooper L, Fullwood N, Gibson M . Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasma. FASEB J. 2003; 17(13):1945-7. DOI: 10.1096/fj.03-0098fje. View

DeMattos R, Bales K, Cummins D, Paul S, Holtzman D . Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science. 2002; 295(5563):2264-7. DOI: 10.1126/science.1067568. View

Miller D, Hague S, Clarimon J, Baptista M, Gwinn-Hardy K, Cookson M . Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication. Neurology. 2004; 62(10):1835-8. DOI: 10.1212/01.wnl.0000127517.33208.f4. View

Borghi R, Marchese R, Negro A, Marinelli L, Forloni G, Zaccheo D . Full length alpha-synuclein is present in cerebrospinal fluid from Parkinson's disease and normal subjects. Neurosci Lett. 2000; 287(1):65-7. DOI: 10.1016/s0304-3940(00)01153-8. View

Dev K, Hofele K, Barbieri S, Buchman V, van der Putten H . Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease. Neuropharmacology. 2003; 45(1):14-44. DOI: 10.1016/s0028-3908(03)00140-0. View

Kruger R, Kuhn W, Muller T, Woitalla D, Graeber M, Kosel S . Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet. 1998; 18(2):106-8. DOI: 10.1038/ng0298-106. View

Ibanez P, Bonnet A, Debarges B, Lohmann E, Tison F, Pollak P . Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet. 2004; 364(9440):1169-71. DOI: 10.1016/S0140-6736(04)17104-3. View

10.

Polymeropoulos M, Lavedan C, Leroy E, Ide S, Dehejia A, Dutra A . Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science. 1997; 276(5321):2045-7. DOI: 10.1126/science.276.5321.2045. View

11.

Gai W, Power J, Blumbergs P, Blessing W . Multiple-system atrophy: a new alpha-synuclein disease?. Lancet. 1998; 352(9127):547-8. DOI: 10.1016/s0140-6736(05)79256-4. View

12.

Jellinger K . Neuropathological spectrum of synucleinopathies. Mov Disord. 2003; 18 Suppl 6:S2-12. DOI: 10.1002/mds.10557. View

13.

Motter R, Kholodenko D, Barbour R, Galasko D, Chang L, Miller B . Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol. 1995; 38(4):643-8. DOI: 10.1002/ana.410380413. View

14.

Zarranz J, Alegre J, Gomez-Esteban J, Lezcano E, Ros R, Ampuero I . The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol. 2004; 55(2):164-73. DOI: 10.1002/ana.10795. View

15.

Tan E, Chandran V, Fook-Chong S, Shen H, Yew K, Teoh M . Alpha-synuclein mRNA expression in sporadic Parkinson's disease. Mov Disord. 2005; 20(5):620-3. DOI: 10.1002/mds.20391. View

16.

Spillantini M, Schmidt M, Lee V, Trojanowski J, Jakes R, Goedert M . Alpha-synuclein in Lewy bodies. Nature. 1997; 388(6645):839-40. DOI: 10.1038/42166. View

17.

Chartier-Harlin M, Kachergus J, Roumier C, Mouroux V, Douay X, Lincoln S . Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet. 2004; 364(9440):1167-9. DOI: 10.1016/S0140-6736(04)17103-1. View

18.

Quinn N . Multiple system atrophy--the nature of the beast. J Neurol Neurosurg Psychiatry. 1989; Suppl:78-89. PMC: 1033311. DOI: 10.1136/jnnp.52.suppl.78. View

19.

Hardy J, Cookson M, Singleton A . Genes and parkinsonism. Lancet Neurol. 2003; 2(4):221-8. DOI: 10.1016/s1474-4422(03)00350-8. View