5. IgE, Mast Cells, Basophils, and Eosinophils

Overview

Journal J Allergy Clin Immunol

Specialty Allergy & Immunology

Date 2006 Feb 4

PMID 16455345

Citations 44

Authors

Calman Prussin

Dean D Metcalfe

Affiliations

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Abstract

IgE, mast cells, basophils, and eosinophils constitute essential elements in allergic inflammation. Allergen-specific IgE, synthesized in response to allergens in the environment, becomes fixed to FcepsilonRI on the membranes of mast cells and basophils. Aggregation of receptor-bound IgE molecules on re-exposure to specific allergen results in the production of mediators that produce the allergic response. Principal among the cells drawn to sites of mediator release is the eosinophil.

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