An Unusual Evolutionary Behaviour of a Sea Urchin Histone Gene Cluster

Overview

Journal EMBO J

Specialties Biotechnology
Molecular Biology

Date 1982 Jan 1

PMID 16453405

Citations 26

Authors

M Busslinger

S Rusconi

M L Birnstiel

Affiliations

Soon will be listed here.

Abstract

DNA sequences of cloned histone coding sequences and spacers of sea urchin species that diverged long ago in evolution were compared. The highly repeated H4 and H3 genes active during early embryogenesis had evolved (in their silent sites) at a rate (0.5-0.6% base changes/Myr) similar to single-copy protein-coding genes and nearly as fast as spacer DNA (0.7% base changes/Myr) and unique DNA. Thus, evolution in the major histone genes conforms to a universal evolutionary clock based on the rate of base sequence change. By contrast, the H4 and H3 coding sequences and a non-transcribed spacer of the DNA clone h19 of Psammechinus miliaris show an exceptionally low rate of sequence evolution only 1/100 to 1/200 that predicted from the clock hypothesis. According to the classical model of gene inheritance, the h19 DNA sequences in the Psammechinus genome require unusual conservation mechanisms by selection at the level of the gene and spacer sequences. An alternative explanation could be recent horizontal gene transfer of a histone gene cluster from the very distantly related Strongylocentrotus dröbachiensis to the P. miliaris genome.

Citing Articles

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The five cleavage-stage (CS) histones of the sea urchin are encoded by a maternally expressed family of replacement histone genes: functional equivalence of the CS H1 and frog H1M (B4) proteins.

Mandl B, Brandt W, Superti-Furga G, Graninger P, Birnstiel M, Busslinger M Mol Cell Biol. 1997; 17(3):1189-200.

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H3 and H4 histone cDNA sequences from Xenopus: a sequence comparison of H4 genes.

Turner P, Woodland H Nucleic Acids Res. 1982; 10(12):3769-80.

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