Intestinal Mucositis: the Role of the Bcl-2 Family, P53 and Caspases in Chemotherapy-induced Damage

Overview

Journal Support Care Cancer

Specialties Critical Care
Oncology

Date 2006 Feb 3

PMID 16453135

Citations 39

Authors

Joanne M Bowen

Rachel J Gibson

Adrian G Cummins

Dorothy M K Keefe

Affiliations

Soon will be listed here.

Abstract

Intestinal mucositis occurs as a consequence of cytotoxic treatment through multiple mechanisms including induction of crypt cell death (apoptosis) and cytostasis. The molecular control of these actions throughout the gastrointestinal tract has yet to be fully elucidated; however, they are known to involve p53, the Bcl-2 family and caspases. This review will provide an overview of current research as well as identify areas where gaps in knowledge exist.

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