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Comparison of the Efficacy of Cilofungin, Fluconazole and Amphotericin B in the Treatment of Systemic Candida Albicans Infection in the Neutropenic Mouse

Overview
Journal Infection
Date 1992 May 1
PMID 1644494
Citations 2
Authors
R M Bannatyne
P C Cheng
I W Fong
Affiliations
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Abstract

The relative efficacies of cilofungin, amphotericin B and fluconazole were compared in the treatment of systemic Candida albicans infection in neutropenic mice. Thirty-one day survival rates were lowest for cilofungin (14.6%), intermediate for amphotericin B (37.6%) and highest for fluconazole (50.5%). Residual tissue infection in surviving animals was observed with all agents, but was heaviest with fluconazole, especially in the kidneys.

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