CD4+CD3- Cells Regulate the Organization of Lymphoid Tissue and T-cell Memory for Antibody Responses

Overview

Journal Int J Hematol

Specialty Hematology

Date 2006 Jan 31

PMID 16443546

Citations 6

Authors

Peter J L Lane

Mi-Yeon Kim

Fabrina M C Gaspal

Fiona M McConnell

Affiliations

Soon will be listed here.

Abstract

This review highlights the role of a CD4(+)CD3(-) accessory cell in the development of organized lymphoid infrastructures as well as in the development of high-affinity antibody responses and T-cell memory. These 2 functions are linked in the development of the vertebrate immune system and are effected by the constitutive expression of 2 sets of tumor necrosis factor (TNF) family members. The expression of lymphotoxin 3 (LT3), LT3, and TNF-3, which are closely linked genetically, affects the organization of lymphoid structures into B-cell and T-cell areas; the dual expression of OX40 ligand (TNFSF4) and CD30 ligand (TNFSF8) influences both the survival of T-cells within germinal centers and T-cell memory.

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