Space Coding by Premotor Cortex

Overview

Journal Exp Brain Res

Specialty Neurology

Date 1992 Jan 1

PMID 1644132

Citations 41

Authors

L Fogassi

V Gallese

G di Pellegrino

L Fadiga

M Gentilucci

G Luppino

M Matelli

A Pedotti

G Rizzolatti

Affiliations

Soon will be listed here.

Abstract

Many neurons in inferior area 6, a cortical premotor area, respond to visual stimuli presented in the space around the animal. We were interested to learn whether the receptive fields of these neurons are coded in retinotopic or in body-centered coordinates. To this purpose we recorded single neurons from inferior area 6 (F4 sector) in a monkey trained to fixate a light and detect its dimming. During fixation visual stimuli were moved towards the monkey both within and outside the neuron's receptive field. The fixation point was then moved and the neuron retested with the monkey's gaze deviated to the new location. The results showed that most inferior area 6 visual neurons code the stimulus position in spatial and not in retinal coordinates. It is proposed that these visual neurons are involved in generating the stable body-centered frame of reference necessary for programming visually guided movements.

Citing Articles

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References

Rizzolatti G, Camarda R, Fogassi L, Gentilucci M, Luppino G, Matelli M . Functional organization of inferior area 6 in the macaque monkey. II. Area F5 and the control of distal movements. Exp Brain Res. 1988; 71(3):491-507. DOI: 10.1007/BF00248742. View

Ferrigno G, Pedotti A . ELITE: a digital dedicated hardware system for movement analysis via real-time TV signal processing. IEEE Trans Biomed Eng. 1985; 32(11):943-50. DOI: 10.1109/TBME.1985.325627. View

Gentilucci M, Scandolara C, Pigarev I, Rizzolatti G . Visual responses in the postarcuate cortex (area 6) of the monkey that are independent of eye position. Exp Brain Res. 1983; 50(2-3):464-8. DOI: 10.1007/BF00239214. View

Matelli M, Luppino G, Rizzolatti G . Patterns of cytochrome oxidase activity in the frontal agranular cortex of the macaque monkey. Behav Brain Res. 1985; 18(2):125-36. DOI: 10.1016/0166-4328(85)90068-3. View

Matsumura M, Kubota K . Cortical projection to hand-arm motor area from post-arcuate area in macaque monkeys: a histological study of retrograde transport of horseradish peroxidase. Neurosci Lett. 1979; 11(3):241-6. DOI: 10.1016/0304-3940(79)90001-6. View

Gentilucci M, Fogassi L, Luppino G, Matelli M, Camarda R, Rizzolatti G . Functional organization of inferior area 6 in the macaque monkey. I. Somatotopy and the control of proximal movements. Exp Brain Res. 1988; 71(3):475-90. DOI: 10.1007/BF00248741. View

Matelli M, Camarda R, Glickstein M, Rizzolatti G . Afferent and efferent projections of the inferior area 6 in the macaque monkey. J Comp Neurol. 1986; 251(3):281-98. DOI: 10.1002/cne.902510302. View

Goldberg M, Bruce C . Primate frontal eye fields. III. Maintenance of a spatially accurate saccade signal. J Neurophysiol. 1990; 64(2):489-508. DOI: 10.1152/jn.1990.64.2.489. View

Andersen R, MOUNTCASTLE V . The influence of the angle of gaze upon the excitability of the light-sensitive neurons of the posterior parietal cortex. J Neurosci. 1983; 3(3):532-48. PMC: 6564545. View

10.

Fuchs A, Robinson D . A method for measuring horizontal and vertical eye movement chronically in the monkey. J Appl Physiol. 1966; 21(3):1068-70. DOI: 10.1152/jappl.1966.21.3.1068. View

11.

Hyvarinen J . Posterior parietal lobe of the primate brain. Physiol Rev. 1982; 62(3):1060-129. DOI: 10.1152/physrev.1982.62.3.1060. View

12.

Andersen R, Essick G, Siegel R . Encoding of spatial location by posterior parietal neurons. Science. 1985; 230(4724):456-8. DOI: 10.1126/science.4048942. View

13.

Schlag J, SCHLAG-REY M, Peck C, Joseph J . Visual responses of thalamic neurons depending on the direction of gaze and the position of targets in space. Exp Brain Res. 1980; 40(2):l70-84. DOI: 10.1007/BF00237535. View

14.

Galletti C, Battaglini P . Gaze-dependent visual neurons in area V3A of monkey prestriate cortex. J Neurosci. 1989; 9(4):1112-25. PMC: 6569849. View

15.

Muakkassa K, Strick P . Frontal lobe inputs to primate motor cortex: evidence for four somatotopically organized 'premotor' areas. Brain Res. 1979; 177(1):176-82. DOI: 10.1016/0006-8993(79)90928-4. View

16.

Pigarev I, Rodionova E . [Neurons with visual receptive fields independent of eye position in the caudal portion of the ventral wall of the cruciate sulcus of the cat cerebral cortex]. Neirofiziologiia. 1986; 18(6):800-5. View