Heterodyne Coherent Anti-Stokes Raman Scattering (CARS) Imaging

Overview

Journal Opt Lett

Specialty Ophthalmology

Date 2006 Jan 31

PMID 16441043

Citations 45

Authors

Eric O Potma

Conor L Evans

X Sunney Xie

Affiliations

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Abstract

We have achieved rapid nonlinear vibrational imaging free of nonresonant background with heterodyne coherent anti-Stokes Raman scattering (CARS) interferometric microscopy. This technique completely separates the real and imaginary responses of nonlinear susceptibility chi(3) and yields a signal that is linear in the concentration of vibrational modes. We show that heterodyne CARS microscopy permits the detection of weak vibrational resonances that are otherwise overshadowed by the strong interference of the nonresonant background.

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