Increased Midbrain Gray Matter in Tourette's Syndrome

Overview

Journal Ann Neurol

Specialty Neurology

Date 2006 Jan 27

PMID 16437578

Citations 23

Authors

Gaetan Garraux

Andrew Goldfine

Stephan Bohlhalter

Alicja Lerner

Takashi Hanakawa

Mark Hallett

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate cerebral structure in Tourette's syndrome (TS).

Methods: Voxel-based morphometry study of high-resolution MRIs in 31 TS patients compared with 31 controls.

Results: Increased gray matter mainly in the left mesencephalon in 31 TS patients.

Interpretation: This result constitutes strong and direct evidence supporting Devinsky's hypothesis (Devinsky O. Neuroanatomy of Gilles de la Tourette's syndrome. Possible midbrain involvement. Arch Neurol 1983;40:508-514) according to which midbrain disturbances play an important pathogenic role in TS.

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