A Potent Depressant Action of Adenine Derivatives on Cerebral Cortical Neurones

Overview

Journal Eur J Pharmacol

Specialty Pharmacology

Date 1975 Jan 1

PMID 164352

Citations 18

Authors

J W Phillis

G K Kostopoulos

J J Limacher

Affiliations

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Abstract

Adenosine and several adenine nucleotides depress the excitability of cerebral cortical neurones, including identified Betz cells. Cyclic 3',5'-adenosine monophosphate was a less effective depressant than various other adenine nucleotides, including cyclic 2',3'-adenosine monophosphate. Adenine and inosine had only weak depressant activity. An initial excitant action of ATP was observed on several neurones. This was succeeded by a depressant effect when the application of ATP was terminated.

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