Synthesis and Biological Activity of Picobenzide (3,5-dimethyl-N-(pyridin-4-ylmethyl)benzamide) Analogues As Potential Antipsychotic Agents

A series of analogues related to picobenzide (CAS 51832-87-2) have been prepared and have been used as starting material to obtain new trisubstituted oxazole derivatives. Two compounds showed a promising pharmacological profile in screening tests of antipsychotic activity, since they affected apomorphine-induced hyperactivity without significant effects on stereotypies.