CD45: All is Not Yet Crystal Clear

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 2006 Jan 21

PMID 16423050

Citations 39

Authors

Nick Holmes

Affiliations

Soon will be listed here.

Abstract

CD45 has been recognized as an important player in regulating signalling in lymphocytes. However, compared with tyrosine kinases, phosphatases are still poorly understood in terms of the details of their specificity and regulation. Here, the recent progress in understanding the biology of the first recognized receptor tyrosine phosphatase, CD45, is reviewed.

Citing Articles

Local delivery of cell surface-targeted immunocytokines programs systemic antitumor immunity.

Santollani L, Maiorino L, Zhang Y, Palmeri J, Stinson J, Duhamel L Nat Immunol. 2024; 25(10):1820-1829.

PMID: 39112631 PMC: 11436379. DOI: 10.1038/s41590-024-01925-7.

Distinct early role of PTEN regulation during HCMV infection of monocytes.

Chesnokova L, Mosher B, Fulkerson H, Nam H, Shakya A, Yurochko A Proc Natl Acad Sci U S A. 2024; 121(12):e2312290121.

PMID: 38483999 PMC: 10962971. DOI: 10.1073/pnas.2312290121.

Local delivery of cell surface-targeted immunocytokines programs systemic anti-tumor immunity.

Santollani L, Zhang Y, Maiorino L, Palmeri J, Stinson J, Duhamel L bioRxiv. 2024; .

PMID: 38260254 PMC: 10802272. DOI: 10.1101/2024.01.03.573641.

CD45-Directed CAR-T Cells with CD45 Knockout Efficiently Kill Myeloid Leukemia and Lymphoma Cells In Vitro Even after Extended Culture.

Harfmann M, Schroder T, Glow D, Jung M, Uhde A, Kroger N Cancers (Basel). 2024; 16(2).

PMID: 38254824 PMC: 10814116. DOI: 10.3390/cancers16020334.

Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy.

Wellhausen N, OConnell R, Lesch S, Engel N, Rennels A, Gonzales D Sci Transl Med. 2023; 15(714):eadi1145.

PMID: 37651540 PMC: 10682510. DOI: 10.1126/scitranslmed.adi1145.

References

Jiang G, den Hertog J, Su J, Noel J, Sap J, Hunter T . Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha. Nature. 1999; 401(6753):606-10. DOI: 10.1038/44170. View

Symons A, Willis A, Barclay A . Domain organization of the extracellular region of CD45. Protein Eng. 1999; 12(10):885-92. DOI: 10.1093/protein/12.10.885. View

Martinez-Pomares L, Crocker P, Da Silva R, Holmes N, Colominas C, Rudd P . Cell-specific glycoforms of sialoadhesin and CD45 are counter-receptors for the cysteine-rich domain of the mannose receptor. J Biol Chem. 1999; 274(49):35211-8. DOI: 10.1074/jbc.274.49.35211. View

Kung C, Okumura M, Seavitt J, Noll M, White L, Pingel J . CD45-associated protein is not essential for the regulation of antigen receptor-mediated signal transduction. Eur J Immunol. 1999; 29(12):3951-5. DOI: 10.1002/(SICI)1521-4141(199912)29:12<3951::AID-IMMU3951>3.0.CO;2-9. View

Ding I, Bruyns E, Li P, Magada D, Paskind M, Rodman L . Biochemical and functional analysis of mice deficient in expression of the CD45-associated phosphoprotein LPAP. Eur J Immunol. 1999; 29(12):3956-61. DOI: 10.1002/(SICI)1521-4141(199912)29:12<3956::AID-IMMU3956>3.0.CO;2-G. View

Kung C, Pingel J, Heikinheimo M, Klemola T, Varkila K, Yoo L . Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease. Nat Med. 2000; 6(3):343-5. DOI: 10.1038/73208. View

Symons A, Cooper D, Barclay A . Characterization of the interaction between galectin-1 and lymphocyte glycoproteins CD45 and Thy-1. Glycobiology. 2000; 10(6):559-63. DOI: 10.1093/glycob/10.6.559. View

Jiang G, den Hertog J, Hunter T . Receptor-like protein tyrosine phosphatase alpha homodimerizes on the cell surface. Mol Cell Biol. 2000; 20(16):5917-29. PMC: 86069. DOI: 10.1128/MCB.20.16.5917-5929.2000. View

Symons A, Barclay A . Molecular basis of antigenic differences between the RT7 alleles of rat CD45. Immunogenetics. 2000; 51(8-9):747-50. DOI: 10.1007/s002510000204. View

10.

Johnson K, Bromley S, Dustin M, Thomas M . A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation. Proc Natl Acad Sci U S A. 2000; 97(18):10138-43. PMC: 27752. DOI: 10.1073/pnas.97.18.10138. View

11.

Diaz del Pozo E, Beverley P, Timon M . Genomic structure and sequence of the leukocyte common antigen (CD45) from the pufferfish Fugu rubripes and comparison with its mammalian homologue. Immunogenetics. 2000; 51(10):838-46. DOI: 10.1007/s002510000214. View

12.

Alexander D . The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function. Semin Immunol. 2000; 12(4):349-59. DOI: 10.1006/smim.2000.0218. View

13.

Fujiki K, Shin D, Nakao M, Yano T . Molecular cloning of carp (Cyprinus carpio) leucocyte cell-derived chemotaxin 2, glia maturation factor beta, CD45 and lysozyme C by use of suppression subtractive hybridisation. Fish Shellfish Immunol. 2000; 10(7):643-50. DOI: 10.1006/fsim.2000.0294. View

14.

Jacobsen M, Schweer D, Ziegler A, Gaber R, Schock S, Schwinzer R . A point mutation in PTPRC is associated with the development of multiple sclerosis. Nat Genet. 2000; 26(4):495-9. DOI: 10.1038/82659. View

15.

Tchilian E, Wallace D, Wells R, Flower D, MORGAN G, Beverley P . A deletion in the gene encoding the CD45 antigen in a patient with SCID. J Immunol. 2001; 166(2):1308-13. DOI: 10.4049/jimmunol.166.2.1308. View

16.

Irie-Sasaki J, Sasaki T, Matsumoto W, Opavsky A, Cheng M, Welstead G . CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 2001; 409(6818):349-54. DOI: 10.1038/35053086. View

17.

Majeti R, Xu Z, Parslow T, Olson J, Daikh D, Killeen N . An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Cell. 2001; 103(7):1059-70. DOI: 10.1016/s0092-8674(00)00209-9. View

18.

Ballingall K, Waibochi L, Holmes E, Woelk C, MacHugh N, Lutje V . The CD45 locus in cattle: allelic polymorphism and evidence for exceptional positive natural selection. Immunogenetics. 2001; 52(3-4):276-83. DOI: 10.1007/s002510000276. View

19.

Su M, Yu C, Burakoff S, Jin Y . Targeting Src homology 2 domain-containing tyrosine phosphatase (SHP-1) into lipid rafts inhibits CD3-induced T cell activation. J Immunol. 2001; 166(6):3975-82. DOI: 10.4049/jimmunol.166.6.3975. View

20.

Martin S, Mehta I, Yokoyama W, Thomas M, Lorenz R . Development of intestinal intraepithelial lymphocytes, NK cells, and NK 1.1+ T cells in CD45-deficient mice. J Immunol. 2001; 166(10):6066-73. DOI: 10.4049/jimmunol.166.10.6066. View