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Release of Mitochondrial DNA Fragments from Brain Mitochondria of Irradiated Mice

Overview
Journal Mitochondrion
Specialty Cell Biology
Date 2006 Jan 18
PMID 16413832
Citations 23
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Abstract

Recently, we demonstrated that the release of mtDNA fragments from mitochondria occurs as a result of the opening of a non-specific pore in the inner mitochondrial membrane. Here, we show that irradiation of mice stimulates the appearance of mtDNA fragments in the cytosolic fractions of the brain. The fragments of mtDNA were found as early as 1h after irradiation, when no observable alteration of mitochondrial functioning occurred. The involvement of mitochondrial permeability transition in this process is discussed.

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