The Epidemiology of Prolactinomas

Overview

Journal Pituitary

Specialty Endocrinology

Date 2006 Jan 18

PMID 16411062

Citations 85

Authors

Antonio Ciccarelli

Adrian F Daly

Albert Beckers

Affiliations

Soon will be listed here.

Abstract

Prolactin-secreting tumors (prolactinomas), the most frequently occurring pituitary tumor, have a frequency that varies with age and sex. They occur most frequently in females aged 20 to 50 years old, at which time the female-to-male ratio is approximately 10:1. In the pediatric-adolescent age group, prolactinomas have a prevalence of 100/million population, and account for less than 2% of all intracranial tumors. Prolactinomas occur in approximately 30% of patients with multiple endocrine neoplasia type 1 and in this setting, they may be more aggressive than their sporadic counterparts. Patients with Carney complex or McCune-Albright syndrome may exhibit hyperprolactinemia due to a pituitary tumor derived from somatomammotropic cells that secrete both growth hormone and prolactin. Few familial cases of prolactinoma unrelated to MEN-1 are reported in literature.

Citing Articles

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Golub D, White T, Shah H, Khaleghi M, Huntoon K, Zandbergen I Pituitary. 2025; 28(1):28.

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Prolactinoma: Navigating the Dual Challenge of Side Effects and Treatment Strategies - A Comprehensive Review.

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Gender Differences in Patients with Prolactinoma: Single-center Ukrainian Experience.

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Prognostic factors for surgical treatment of prolactin-secreting pituitary adenomas.

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[Overcoming therapy resistance in prolactinomas: from perspectives to real clinical practice].

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