Aldosterone Target Neurons in the Nucleus Tractus Solitarius Drive Sodium Appetite

Overview

Journal J Neurosci

Specialty Neurology

Date 2006 Jan 13

PMID 16407537

Citations 74

Authors

Joel C Geerling

William C Engeland

Mitsuhiro Kawata

Arthur D Loewy

Affiliations

Soon will be listed here.

Abstract

Sodium appetite can be enhanced by the adrenal steroid aldosterone via an unknown brain mechanism. A novel group of neurons in the nucleus tractus solitarius expresses the enzyme 11-beta-hydroxysteroid dehydrogenase type 2, which makes them selectively responsive to aldosterone. Their activation parallels sodium appetite in different paradigms of salt loss even in the absence of aldosterone. These unique aldosterone target neurons may represent a previously unrecognized central convergence point at which hormonal and neural signals can be integrated to drive sodium appetite.

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Aldosterone-induced salt appetite requires HSD2 neurons.

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