Childhood Sleep-disordered Breathing and Its Implications for Cardiac and Vascular Diseases

Overview

Journal J Paediatr Child Health

Specialty Pediatrics

Date 2006 Jan 10

PMID 16398867

Citations 14

Authors

D K Ng

C Chan

A S Chow

P Chow

K Kwok

Affiliations

Soon will be listed here.

Abstract

Objective: To systematically evaluate the recent literature regarding the relationship between childhood sleep-disordered breathing (SDB)/obstructive sleep apnoea (OSA) and cardiovascular diseases in children.

Methods: The literature about SDB/OSA and blood pressure, sympathetic activation, arterial distensibility, ventricular hypertrophy and insulin resistance were studied. Meta-analysis of risk of hypertension and high apnoea-hyponoea index were performed to calculate the combined odds ratio and it is equal to 2.93 (95% CI = 1.18-7.29).

Results: The results suggest a significant association between SDB/OSA and hypertension. However, the data are not adequate to draw firm conclusion although evidences were emerging to suggest that SDB/OSA affects blood pressure in either directions in children. Limited evidences also suggest that SDB/OSA is associated with increased sympathetic activation, decreased arterial distensibility and ventricular hypertrophy.

Conclusions: There is now increasing but not adequate evidence that childhood SDB/OSA is associated with detectable cardiovascular abnormalities.

Citing Articles

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Rodriguez-Lopez S, Palkowski S, Gerdung C, Keto-Lambert D, Sebastianski M, Castro-Codesal M BMJ Open. 2020; 10(8):e039342.

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Liu X, Immanuel S, Kennedy D, Martin J, Pamula Y, Baumert M Sleep. 2018; 41(11).

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Longitudinal Cardiovascular Outcomes of Sleep Disordered Breathing in Children: A Meta-Analysis and Systematic Review.

Ehsan Z, Ishman S, Kimball T, Zhang N, Zou Y, Amin R Sleep. 2017; 40(3).

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