The Bifidobacterium Longum NCIMB 702259T Ctr Gene Codes for a Novel Cholate Transporter

Overview

Journal Appl Environ Microbiol

Specialties Environmental Health
Microbiology

Date 2006 Jan 5

PMID 16391136

Citations 22

Authors

Claire E Price

Sharon J Reid

Arnold J M Driessen

Valerie R Abratt

Affiliations

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Abstract

Preexposure of Bifidobacterium longum NCIMB 702259T to cholate caused increased resistance to cholate, chloramphenicol, and erythromycin. The B. longum ctr gene, encoding a cholate efflux transporter, was transformed into the efflux-negative mutant Escherichia coli KAM3, conferring resistance to bile salts and other antimicrobial compounds and causing the efflux of [14C]cholate.

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