Sample Sizes for Self-controlled Case Series Studies

Overview

Journal Stat Med

Publisher Wiley

Specialty Public Health

Date 2005 Dec 24

PMID 16372391

Citations 34

Authors

Patrick Musonda

C Paddy Farrington

Heather J Whitaker

Affiliations

Soon will be listed here.

Abstract

We derive several formulae for the sample size required for a study designed using the self-controlled case series method without age effects. We investigate these formulae by simulation, and identify one based on the signed root likelihood ratio statistic which performs well. We extend this method to allow for age effects, which can have a big impact on the sample size needed. This more general sample size formula is also found to perform well in a broad range of situations.

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