Near Death Experiences: Poxvirus Regulation of Apoptotic Death

Overview

Journal Virology

Specialty Microbiology

Date 2005 Dec 21

PMID 16364745

Citations 50

Authors

John M Taylor

Michele Barry

Affiliations

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Abstract

Apoptosis, or programmed cell death, plays a critical role in the elimination of virus-infected cells. As a result, a growing number of viruses encode numerous potent anti-apoptotic proteins to counteract apoptosis in an effort to prolong their own survival. This review describes the numerous mechanisms by which poxviruses inhibit apoptosis thereby modulating life and death of the cell.

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