Epidermal Growth Factor Receptor is a Common Element in the Signaling Pathways Activated by Cell Volume Changes in Isosmotic, Hyposmotic or Hyperosmotic Conditions

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2005 Dec 20

PMID 16362778

Citations 12

Authors

R Lezama

A Diaz-Tellez

G Ramos-Mandujano

L Oropeza

H Pasantes-Morales

Affiliations

Soon will be listed here.

Abstract

Changes in external osmolarity, including both hyper- or hyposmotic conditions, elicit the tyrosine phosphorylation of a number of tyrosine kinase receptors (TKR). We show here that the epidermal growth factor receptor (EGFR) is activated by both cell swelling (hyposmolarity, isosmotic urea, hyperosmotic sorbitol) or shrinkage (hyperosmotic NaCl or raffinose) and discuss the mechanisms by which these apparently opposed conditions come to the same effect, i.e., EGFR activation. Evidence suggests that this results from early activation of integrins, p38 and tyrosine kinases of the Src family, which are all activated in the two anisosmotic conditions. TKR transactivation by integrins and p38 is likely occurring via an effect on the metalloproteinases. Information discussed in this review, points to TKR as elements in osmotransduction as a useful mechanism to amplify and diversify the initial response to anisosmolarity and cell volume changes, due to their privileged situation as convergence point for numerous intracellular signaling pathways. The variety of effector pathways connected to TKR is advantageous for the cell to cope with the changes in cell volume including adaptation to stress, cytoskeleton remodeling, adhesion reactions, cell survival and the adaptive mechanisms to ultimately restore the original cell volume.

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References

Schlessinger J . Cell signaling by receptor tyrosine kinases. Cell. 2000; 103(2):211-25. DOI: 10.1016/s0092-8674(00)00114-8. View

Li C, Xu Q . Mechanical stress-initiated signal transductions in vascular smooth muscle cells. Cell Signal. 2000; 12(7):435-45. DOI: 10.1016/s0898-6568(00)00096-6. View

Kracke G, Preston G, Stanley T . Identification of a sorbitol permease in human erythrocytes. Am J Physiol. 1994; 266(2 Pt 1):C343-50. DOI: 10.1152/ajpcell.1994.266.2.C343. View

Xu H, Tian W, Lindsley J, Oyama T, Capasso J, Rivard C . EphA2: expression in the renal medulla and regulation by hypertonicity and urea stress in vitro and in vivo. Am J Physiol Renal Physiol. 2004; 288(4):F855-66. DOI: 10.1152/ajprenal.00347.2004. View

Yang T, Zhang A, Honeggar M, Kohan D, Mizel D, Sanders K . Hypertonic induction of COX-2 in collecting duct cells by reactive oxygen species of mitochondrial origin. J Biol Chem. 2005; 280(41):34966-73. DOI: 10.1074/jbc.M502430200. View

Tilly B, Gaestel M, Engel K, Edixhoven M, de Jonge H . Hypo-osmotic cell swelling activates the p38 MAP kinase signalling cascade. FEBS Lett. 1996; 395(2-3):133-6. DOI: 10.1016/0014-5793(96)01028-9. View

Uhlik M, Abell A, Johnson N, Sun W, Cuevas B, Lobel-Rice K . Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock. Nat Cell Biol. 2003; 5(12):1104-10. DOI: 10.1038/ncb1071. View

Sheikh-Hamad D, Gustin M . MAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals. Am J Physiol Renal Physiol. 2004; 287(6):F1102-10. DOI: 10.1152/ajprenal.00225.2004. View

Sardini A, Amey J, Weylandt K, Nobles M, Valverde M, Higgins C . Cell volume regulation and swelling-activated chloride channels. Biochim Biophys Acta. 2004; 1618(2):153-62. DOI: 10.1016/j.bbamem.2003.10.008. View

10.

Walz W . Role of astrocytes in the clearance of excess extracellular potassium. Neurochem Int. 2000; 36(4-5):291-300. DOI: 10.1016/s0197-0186(99)00137-0. View

11.

Wehner F, Olsen H, Tinel H, Kinne-Saffran E, Kinne R . Cell volume regulation: osmolytes, osmolyte transport, and signal transduction. Rev Physiol Biochem Pharmacol. 2003; 148:1-80. DOI: 10.1007/s10254-003-0009-x. View

12.

Dahl S, Schliess F, Reissmann R, Gorg B, Weiergraber O, Kocalkova M . Involvement of integrins in osmosensing and signaling toward autophagic proteolysis in rat liver. J Biol Chem. 2003; 278(29):27088-95. DOI: 10.1074/jbc.M210699200. View

13.

Pasantes-Morales H, Franco R, Ordaz B, Ochoa L . Mechanisms counteracting swelling in brain cells during hyponatremia. Arch Med Res. 2002; 33(3):237-44. DOI: 10.1016/s0188-4409(02)00353-3. View

14.

Moro L, Venturino M, Bozzo C, Silengo L, Altruda F, Beguinot L . Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival. EMBO J. 1998; 17(22):6622-32. PMC: 1171008. DOI: 10.1093/emboj/17.22.6622. View

15.

Nahm O, Woo S, Handler J, Kwon H . Involvement of multiple kinase pathways in stimulation of gene transcription by hypertonicity. Am J Physiol Cell Physiol. 2001; 282(1):C49-58. DOI: 10.1152/ajpcell.00267.2001. View

16.

Pasantes-Morales H, Franco R, Torres-Marquez M, Hernandez-Fonseca K, Ortega A . Amino acid osmolytes in regulatory volume decrease and isovolumetric regulation in brain cells: contribution and mechanisms. Cell Physiol Biochem. 2000; 10(5-6):361-70. DOI: 10.1159/000016369. View

17.

Lunn J, Rozengurt E . Hyperosmotic stress induces rapid focal adhesion kinase phosphorylation at tyrosines 397 and 577. Role of Src family kinases and Rho family GTPases. J Biol Chem. 2004; 279(43):45266-78. DOI: 10.1074/jbc.M314132200. View

18.

Rosette C, Karin M . Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science. 1996; 274(5290):1194-7. DOI: 10.1126/science.274.5290.1194. View

19.

Xu D, Wang L, Olson J, Lu L . Asymmetrical response of p38 kinase activation to volume changes in primary rat astrocytes. Exp Biol Med (Maywood). 2001; 226(10):927-33. DOI: 10.1177/153537020122601008. View

20.

Boudreau N, Jones P . Extracellular matrix and integrin signalling: the shape of things to come. Biochem J. 1999; 339 ( Pt 3):481-8. PMC: 1220180. View