ADPKD: Molecular Characterization and Quest for Treatment

Overview

Journal Clin Exp Nephrol

Publisher Springer

Specialty Nephrology

Date 2005 Dec 20

PMID 16362154

Citations 3

Authors

Shigeo Horie

Affiliations

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Abstract

Autosomal-dominant polycystic kidney disease (ADPKD) is a common hereditary disease that features multiple cystogenesis in various organs and vascular defects. The genes responsible for ADPKD, PKD1, and PKD2 have been identified, and the pathological processes of the disease are becoming clearer. This review focuses on recent findings about the molecular and cellular biology of ADPKD, and especially on PKD1. PKD1 and its product, polycystin-1, play pivotal roles in cellular differentiation because they regulate the cell cycle and because polycystin-1 is a component of adherens junctions. A possible link between polycystin-1 and PPARgamma is discussed. The extraordinarily fast research progress in this area in the last decade has now reached a stage where the development of a remedy for ADPKD might become possible in the near future.

Citing Articles

Mutation Is a Biomarker for Autosomal Dominant Polycystic Kidney Disease.

Kimura T, Kawano H, Muto S, Muramoto N, Takano T, Lu Y Biomolecules. 2023; 13(7).

PMID: 37509056 PMC: 10377076. DOI: 10.3390/biom13071020.

Human Evaluation of the Glu298Asp Polymorphism in NOS3 Gene and its Relationship with Onset age of ESRD in Iranian Patients Suffering from ADPKD.

Dasar N, Ghaderian S, Azargashb E Int J Mol Cell Med. 2014; 1(2):105-12.

PMID: 24551766 PMC: 3920495.

Autosomal dominant polycystic kidney disease: recent advances in pathogenesis and potential therapies.

Mochizuki T, Tsuchiya K, Nitta K Clin Exp Nephrol. 2012; 17(3):317-26.

PMID: 23192769 DOI: 10.1007/s10157-012-0741-0.

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