GABAB Receptor: a Site of Therapeutic Benefit

Overview

Journal Curr Opin Pharmacol

Specialty Pharmacology

Date 2005 Dec 20

PMID 16361115

Citations 80

Authors

Norman G Bowery

Affiliations

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Abstract

Although the presence of functional GABAB receptors in mammalian brain has been known for more than 20 years, there is still only one therapeutic agent in use, baclofen, which mediates its effects directly via this receptor. However, activation of this receptor can produce numerous effects that might be amenable to drug development. Evidence from preclinical studies also suggests that antagonism of the GABAB receptor produces beneficial clinical effects.

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