The MicroRNA Pathway Plays a Regulatory Role in Stem Cell Division

Overview

Journal Cell Cycle

Specialty Cell Biology

Date 2005 Dec 17

PMID 16357538

Citations 37

Authors

H R Shcherbata

S Hatfield

E J Ward

S Reynolds

K A Fischer

H Ruohola-Baker

Affiliations

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Abstract

One of the key characteristics of stem cells is their capacity for self-renewal for long periods of time. In this respect, stem cells are similar to cancer cells, which also have the ability to escape cell cycle stop signals. Therefore, a critical question in stem cell and cancer biology is how cell division is regulated in these cell types. In this review, we summarize recent progress and describe future challenges to understanding the role the microRNA pathway plays in regulating mechanisms controlling stem cell division.

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