Selective Activation of TACI by Syndecan-2

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2005 Dec 17

PMID 16357320

Citations 25

Authors

Daniela Bischof

Sherine F Elsawa

George Mantchev

Juhan Yoon

Grace E Michels

Allan Nilson

Shari L Sutor

Jeffrey L Platt

Stephen M Ansell

Gotz von Bulow

Richard J Bram

Affiliations

Soon will be listed here.

Abstract

B-lymphocyte homeostasis and function are regulated by complementary actions of the TNFR family members TACI, BCMA, and BAFF-R, which are expressed by mature B cells. How these receptors are differentially activated is not entirely understood, because the primary ligand BAFF binds to all three. We searched for alternative ligands for TACI using recombinant TACI-Fc fusion protein as a probe and identified syndecan-2 as a new binding partner. TACI binding appears to require heparan sulfate posttranslational modifications of syndecan-2, because free heparin or pretreatment with heparitinase blocked the interaction. Syndecan-2 bound TACI but bound neither BAFF-R nor BCMA. Transfected cells expressing syndecan-2 activated signaling through TACI, as indicated by an NFAT-specific reporter. Syndecan-1 and syndecan-4 were also able to induce TACI signaling in a similar manner. This is the first identification of ligands that selectively activate TACI without simultaneously triggering BCMA or BAFF-R. This finding may help explain the alternative outcomes of signaling from this family of receptors in B cells.

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