Dysregulation of Receptor Interacting Protein-2 and Caspase Recruitment Domain Only Protein Mediates Aberrant Caspase-1 Activation in Huntington's Disease

Overview

Journal J Neurosci

Specialty Neurology

Date 2005 Dec 16

PMID 16354923

Citations 16

Authors

Xin Wang

Hongyan Wang

Bryan E Figueroa

Wen-Hua Zhang

Chunfeng Huo

Yingjun Guan

Yu Zhang

Jean-Marie Bruey

John C Reed

Robert M Friedlander

Affiliations

Soon will be listed here.

Abstract

Caspase-1 plays a role in the pathogenesis of a variety of neurological diseases. Caspase-1 activation is an early event in models of Huntington's disease (HD). However, mechanisms regulating the activation of this apical caspase in cell death are not known. Receptor interacting protein-2 (Rip2) and caspase recruitment domain (CARD) only protein (Cop) are two CARD proteins with significant homology to the caspase-1 CARD and modulate caspase-1 activation in inflammation. Rip2 is a caspase-1 activator, and Cop is a caspase-1 inhibitor. We demonstrate in models of HD that caspase-1 activation results from dysregulation of caspase-1 activation pathways. Associated with disease progression, we detect elevation of the caspase-1 activator Rip2 and reduction of the caspase-1 inhibitor Cop. Knocking down endogenous Rip2/Cop respectively results in reduced/increased sensitivity to neurotoxic stimuli. Our data provide evidence that caspase-1-mediated cell death is regulated, at least in part, by the balance of Rip2 and Cop, and alterations of this balance may contribute to aberrant caspase-1-mediated pathogenesis in Huntington's disease.

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References

Klevenyi P, Andreassen O, Ferrante R, Schleicher Jr J, Friedlander R, Beal M . Transgenic mice expressing a dominant negative mutant interleukin-1beta converting enzyme show resistance to MPTP neurotoxicity. Neuroreport. 1999; 10(3):635-8. DOI: 10.1097/00001756-199902250-00035. View

Ona V, Li M, Vonsattel J, ANDREWS L, Khan S, Chung W . Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature. 1999; 399(6733):263-7. DOI: 10.1038/20446. View

Zhu S, Sheng J, Jones R, Brewer M, Zhou X, Mrak R . Increased interleukin-1beta converting enzyme expression and activity in Alzheimer disease. J Neuropathol Exp Neurol. 1999; 58(6):582-7. DOI: 10.1097/00005072-199906000-00002. View

Masumoto J, Taniguchi S, Ayukawa K, Sarvotham H, Kishino T, Niikawa N . ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells. J Biol Chem. 1999; 274(48):33835-8. DOI: 10.1074/jbc.274.48.33835. View

Fink K, ANDREWS L, Butler W, Ona V, Li M, Bogdanov M . Reduction of post-traumatic brain injury and free radical production by inhibition of the caspase-1 cascade. Neuroscience. 2000; 94(4):1213-8. DOI: 10.1016/s0306-4522(99)00345-0. View

Li M, Ona V, Guegan C, Chen M, Jackson-Lewis V, ANDREWS L . Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science. 2000; 288(5464):335-9. DOI: 10.1126/science.288.5464.335. View

Rigamonti D, Bauer J, Conti L, Sipione S, Sciorati C, Clementi E . Wild-type huntingtin protects from apoptosis upstream of caspase-3. J Neurosci. 2000; 20(10):3705-13. PMC: 6772672. View

Rabuffetti M, Sciorati C, Tarozzo G, Clementi E, Manfredi A, Beltramo M . Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp-chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines. J Neurosci. 2000; 20(12):4398-404. PMC: 6772438. View

Chen M, Ona V, Li M, Ferrante R, Fink K, Zhu S . Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med. 2000; 6(7):797-801. DOI: 10.1038/77528. View

10.

Li M, Ona V, Chen M, Kaul M, Tenneti L, Zhang X . Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury. Neuroscience. 2000; 99(2):333-42. DOI: 10.1016/s0306-4522(00)00173-1. View

11.

Li X . The early cellular pathology of Huntington's disease. Mol Neurobiol. 2000; 20(2-3):111-24. DOI: 10.1007/BF02742437. View

12.

Li S, Lam S, Cheng A, Li X . Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis. Hum Mol Genet. 2000; 9(19):2859-67. DOI: 10.1093/hmg/9.19.2859. View

13.

Engidawork E, Gulesserian T, Yoo B, Cairns N, Lubec G . Alteration of caspases and apoptosis-related proteins in brains of patients with Alzheimer's disease. Biochem Biophys Res Commun. 2001; 281(1):84-93. DOI: 10.1006/bbrc.2001.4306. View

14.

Fankhauser C, Friedlander R, Gagliardini V . Prevention of nuclear localization of activated caspases correlates with inhibition of apoptosis. Apoptosis. 2001; 5(2):117-32. DOI: 10.1023/a:1009672411058. View

15.

Goyal L . Cell death inhibition: keeping caspases in check. Cell. 2001; 104(6):805-8. DOI: 10.1016/s0092-8674(01)00276-8. View

16.

Ilzecka J, Stelmasiak Z, Dobosz B . Interleukin-1beta converting enzyme/Caspase-1 (ICE/Caspase-1) and soluble APO-1/Fas/CD 95 receptor in amyotrophic lateral sclerosis patients. Acta Neurol Scand. 2001; 103(4):255-8. View

17.

Poyet J, Srinivasula S, Tnani M, Razmara M, Fernandes-Alnemri T, Alnemri E . Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. J Biol Chem. 2001; 276(30):28309-13. DOI: 10.1074/jbc.C100250200. View

18.

Lee S, Stehlik C, Reed J . Cop, a caspase recruitment domain-containing protein and inhibitor of caspase-1 activation processing. J Biol Chem. 2001; 276(37):34495-500. DOI: 10.1074/jbc.M101415200. View

19.

Druilhe A, Srinivasula S, Razmara M, Ahmad M, Alnemri E . Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. Cell Death Differ. 2001; 8(6):649-57. DOI: 10.1038/sj.cdd.4400881. View

20.

Benchoua A, Guegan C, Couriaud C, Hosseini H, Sampaio N, Morin D . Specific caspase pathways are activated in the two stages of cerebral infarction. J Neurosci. 2001; 21(18):7127-34. PMC: 6762989. View