Expression of M157, a Murine Cytomegalovirus-encoded Putative Major Histocompatibility Class I (MHC-I)-like Protein, is Independent of Viral Regulation of Host MHC-I

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2005 Dec 15

PMID 16352579

Citations 29

Authors

Sandeep K Tripathy

Hamish R C Smith

Erika A Holroyd

Jeanette T Pingel

Wayne M Yokoyama

Affiliations

Soon will be listed here.

Abstract

A murine cytomegalovirus (MCMV)-encoded protein, m157, has a putative major histocompatibility complex class I (MHC-I) structure and is recognized by the Ly49H NK cell activation receptor. Using a monoclonal antibody against m157, in this study we directly demonstrated that m157 is a cell surface-expressed glycophosphatidylinositol-anchored protein with early viral gene kinetics. Beta-2 microglobulin and TAP1 (transporter associated with antigen processing 1) were not required for its expression. MCMV-encoded proteins that down-regulate MHC-I did not affect the expression of m157. Thus, m157 is expressed on infected cells in a manner independent of viral regulation of host MHC-I.

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