Enzymic Dehalogenation of 4-Chlorobenzoyl Coenzyme A in Acinetobacter Sp. Strain 4-CB1

Overview

Journal Appl Environ Microbiol

Specialties Environmental Health
Microbiology

Date 1992 Apr 1

PMID 16348702

Citations 6

Authors

S D Copley

G P Crooks

Affiliations

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Abstract

4-Chlorobenzoate degradation in cell extracts of Acinetobacter sp. strain 4-CB1 occurs by initial synthesis of 4-chlorobenzoyl coenzyme A (4-chlorobenzoyl CoA) from 4-chlorobenzoate, CoA, and ATP. 4-Chlorobenzoyl CoA is dehalogenated to 4-hydroxybenzoyl CoA. Following the dehalogenation reaction, 4-hydroxybenzoyl CoA is hydrolyzed to 4-hydroxybenzoate and CoA. Possible roles for the CoA moiety in the dehalogenation reaction are discussed.

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