Allosensitization in Patients Receiving Multiple Blood Transfusions

Overview

Journal Ann N Y Acad Sci

Specialty Science

Date 2005 Dec 13

PMID 16339705

Citations 20

Authors

V S Sakhalkar

K Roberts

L M Hawthorne

D M McCaskill

D M Veillon

G C Caldito

J D Cotelingam

Affiliations

Soon will be listed here.

Abstract

Extended antigen (C, E, K) matching decreased the incidence of alloantibody (alloAB) and autoantibody (autoAB) formation, in addition to eliminating transfusion reactions in the multiply transfused sickle cell disease patients. AlloAB formation possibly transforms the immune system into a hyperactive state leading to further and earlier alloAB and autoAB formation. However, additional CEK matching results in marked overuse of Rh-negative packed red blood cell (pRBC) units, 30 minutes' extra time of a skilled technologist, and 153 dollars extra CEK reagent cost per unit to find CEK-matched pRBCs for every transfusion for these multiply transfused patients.

Citing Articles

Red Cell Alloimmunisation Among Sickle Cell Disease and Thalassemia Patients Following Rh- and K-Matched Red Cell Transfusion in Southwestern Saudi Arabia: A Multicenter Study.

Meshi A, Abu-Tawil H, Hamzi A, Madkhali B, Maghfori A, Alnami I Int J Gen Med. 2024; 17:2855-2864.

PMID: 38947563 PMC: 11212813. DOI: 10.2147/IJGM.S444949.

When the available blood supply mismatches the needs of the patient.

Weidner L, Allhoff W, Pistorius C, Witt V, Rohde E, Schistal E Blood Transfus. 2022; 21(5):378-384.

PMID: 36346886 PMC: 10497382. DOI: 10.2450/2022.0166-22.

Rh alloimmunization in chronically transfused patients with thalassemia receiving RhD, C, E, and K matched transfusions.

Waldis S, Uter S, Kavitsky D, Flickinger C, Vege S, Friedman D Blood Adv. 2021; 5(3):737-744.

PMID: 33560383 PMC: 7876880. DOI: 10.1182/bloodadvances.2020003732.

Transfusion and Cellular Therapy in Pediatric Sickle Cell Disease.

Zheng Y, Chou S Clin Lab Med. 2021; 41(1):101-119.

PMID: 33494879 PMC: 7842358. DOI: 10.1016/j.cll.2020.10.007.

Rh antibodies as a result of altered Rh epitopes on transfused red cells: a case series of seven Brazilian patients.

Macedo M, Miranda M, Santos T, Leal I, Castilho L Blood Transfus. 2020; 19(5):413-419.

PMID: 33085591 PMC: 8486610. DOI: 10.2450/2020.0073-20.