The Effects of Vitamin C Supplementation on Oxidative Stress and Antioxidant Content in the Brains of Chronically Exercised Rats

Overview

Journal Mol Cell Biochem

Publisher Springer

Specialty Biochemistry

Date 2005 Nov 29

PMID 16311914

Citations 10

Authors

Sule Coskun

Bilge Gonul

Nevin Atalay Guzel

Barbaros Balabanli

Affiliations

Soon will be listed here.

Abstract

The purpose of this study was to ascertain whether vitamin C supplementation during chronic exercise training alters rat brain antioxidant content. Female Wistar albino rats were exercised on a treadmill for 30 min/day for 6.5 weeks and were administered daily intraperitoneal injections of vitamin C (20 mg/kg). After the training period, chronically exercised rats showed no significant changes in total brain thiobarbituric acid reactive substances (TBARS) levels. In contrast, rats supplemented with vitamin C during the training period showed significantly elevated brain TBARS levels. If such results were extrapolated to man, where vitamin supplementation is a common practice, this would indicate that vitamin C supplementation may not protect brain tissue against exercise-induced oxidative damage, in such circumstances, this water-soluble antioxidant behaves as a pro-oxidant.

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