A Twist for Survival and Cancer Progression

Overview

Journal Br J Cancer

Specialty Oncology

Date 2005 Nov 25

PMID 16306876

Citations 104

Authors

A Puisieux

S Valsesia-Wittmann

S Ansieau

Affiliations

Soon will be listed here.

Abstract

A major obstacle to the expansion of abnormal cells with significant proliferative potential is the induction of programmed cell death. Consequently, oncogene-driven hyperproliferation must be associated with apoptosis inhibition to allow malignant outgrowth. The oncogenic cooperation of N-Myc and Twist-1 in the development of neuroblastoma, the most common and deadly solid tumour of childhood, perfectly illustrates such a process. N-Myc promotes cell proliferation, whereas Twist-1 counteracts its pro-apoptotic properties by knocking-down the ARF/p53 pathway. On the basis of numerous recent studies reporting its overexpression in a variety of human cancers, we discuss in this review the role of Twist-1 as a potent inhibitor of the cell safety programs engaged in response to an abnormal mitogenic activity.

Citing Articles

Effect of silencing Ras homolog family member C on proliferation, invasion, and migration of salivary adenoid cystic carcinoma.

Yu W, Zhao P, Shao Y, Xu Y, Xu J, Xie L Hua Xi Kou Qiang Yi Xue Za Zhi. 2024; 42(6):723-734.

PMID: 39610069 PMC: 11669934. DOI: 10.7518/hxkq.2024.2024092.

The significant others of aurora kinase a in cancer: combination is the key.

Nikhil K, Shah K Biomark Res. 2024; 12(1):109.

PMID: 39334449 PMC: 11438406. DOI: 10.1186/s40364-024-00651-4.

Transcription Factors and Markers Related to Epithelial-Mesenchymal Transition and Their Role in Resistance to Therapies in Head and Neck Cancers.

Pawlicka M, Gumbarewicz E, Blaszczak E, Stepulak A Cancers (Basel). 2024; 16(7).

PMID: 38611032 PMC: 11010970. DOI: 10.3390/cancers16071354.

Elucidating the role of TWIST1 in ulcerative colitis: a comprehensive bioinformatics and machine learning approach.

Ou W, Qi Z, Liu N, Zhang J, Mi X, Song Y Front Genet. 2024; 15:1296570.

PMID: 38510272 PMC: 10952112. DOI: 10.3389/fgene.2024.1296570.

Combined DNA Methylation and Gastric Microbiome Marker Predicts -Negative Gastric Cancer.

Kim M, Kim H, Jacobs J, Yang H Gut Liver. 2024; 18(4):611-620.

PMID: 38509701 PMC: 11249944. DOI: 10.5009/gnl230348.

References

Zindy F, Eischen C, Randle D, Kamijo T, Cleveland J, Sherr C . Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev. 1998; 12(15):2424-33. PMC: 317045. DOI: 10.1101/gad.12.15.2424. View

Watanabe O, Imamura H, Shimizu T, Kinoshita J, Okabe T, Hirano A . Expression of twist and wnt in human breast cancer. Anticancer Res. 2005; 24(6):3851-6. View

Wang X, Ling M, Guan X, Tsao S, Cheung H, Lee D . Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells. Oncogene. 2004; 23(2):474-82. DOI: 10.1038/sj.onc.1207128. View

Sosic D, Richardson J, Yu K, Ornitz D, Olson E . Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell. 2003; 112(2):169-80. DOI: 10.1016/s0092-8674(03)00002-3. View

Ip Y, Park R, Kosman D, Bier E, Levine M . The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo. Genes Dev. 1992; 6(9):1728-39. DOI: 10.1101/gad.6.9.1728. View

Martin T, Goyal A, Watkins G, Jiang W . Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer. Ann Surg Oncol. 2005; 12(6):488-96. DOI: 10.1245/ASO.2005.04.010. View

Leptin M . twist and snail as positive and negative regulators during Drosophila mesoderm development. Genes Dev. 1991; 5(9):1568-76. DOI: 10.1101/gad.5.9.1568. View

Tarin D, Thompson E, Newgreen D . The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res. 2005; 65(14):5996-6000. DOI: 10.1158/0008-5472.CAN-05-0699. View

Huber M, Kraut N, Beug H . Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol. 2005; 17(5):548-58. DOI: 10.1016/j.ceb.2005.08.001. View

10.

Hoek K, Rimm D, Williams K, Zhao H, Ariyan S, Lin A . Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res. 2004; 64(15):5270-82. DOI: 10.1158/0008-5472.CAN-04-0731. View

11.

Maestro R, Dei Tos A, Hamamori Y, Krasnokutsky S, Sartorelli V, Kedes L . Twist is a potential oncogene that inhibits apoptosis. Genes Dev. 1999; 13(17):2207-17. PMC: 317004. DOI: 10.1101/gad.13.17.2207. View

12.

Howe L, Watanabe O, Leonard J, Brown A . Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation. Cancer Res. 2003; 63(8):1906-13. View

13.

Evan G, Wyllie A, GILBERT C, Littlewood T, Land H, Brooks M . Induction of apoptosis in fibroblasts by c-myc protein. Cell. 1992; 69(1):119-28. DOI: 10.1016/0092-8674(92)90123-t. View

14.

van Doorn R, Dijkman R, Vermeer M, Out-Luiting J, van der Raaij-Helmer E, Willemze R . Aberrant expression of the tyrosine kinase receptor EphA4 and the transcription factor twist in Sézary syndrome identified by gene expression analysis. Cancer Res. 2004; 64(16):5578-86. DOI: 10.1158/0008-5472.CAN-04-1253. View

15.

Dupont J, Fernandez A, Glackin C, Helman L, LeRoith D . Insulin-like growth factor 1 (IGF-1)-induced twist expression is involved in the anti-apoptotic effects of the IGF-1 receptor. J Biol Chem. 2001; 276(28):26699-707. DOI: 10.1074/jbc.M102664200. View

16.

Kwok W, Ling M, Lee T, Lau T, Zhou C, Zhang X . Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Cancer Res. 2005; 65(12):5153-62. DOI: 10.1158/0008-5472.CAN-04-3785. View

17.

Pantke O, Cohen Jr M, WITKOP Jr C, Feingold M, Schaumann B, Pantke H . The Saethre-Chotzen syndrome. Birth Defects Orig Artic Ser. 1975; 11(2):190-225. View

18.

Heimann R, Lan F, McBride R, Hellman S . Separating favorable from unfavorable prognostic markers in breast cancer: the role of E-cadherin. Cancer Res. 2000; 60(2):298-304. View

19.

Raval A, Lucas D, Matkovic J, Bennett K, Liyanarachchi S, Young D . TWIST2 demonstrates differential methylation in immunoglobulin variable heavy chain mutated and unmutated chronic lymphocytic leukemia. J Clin Oncol. 2005; 23(17):3877-85. DOI: 10.1200/JCO.2005.02.196. View

20.

Li L, Cserjesi P, Olson E . Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis. Dev Biol. 1995; 172(1):280-92. DOI: 10.1006/dbio.1995.0023. View