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Estimation of the Number of Nucleotide Substitutions when There Are Strong Transition-transversion and G+C-content Biases

Overview
Journal Mol Biol Evol
Specialty Biology
Date 1992 Jul 1
PMID 1630306
Citations 665
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Abstract

A simple mathematical method is developed to estimate the number of nucleotide substitutions per site between two DNA sequences, by extending Kimura's (1980) two-parameter method to the case where a G+C-content bias exists. This method will be useful when there are strong transition-transversion and G+C-content biases, as in the case of Drosophila mitochondrial DNA.

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