Estimation of the Number of Nucleotide Substitutions when There Are Strong Transition-transversion and G+C-content Biases

Overview

Journal Mol Biol Evol

Publisher Oxford University Press

Specialty Biology

Date 1992 Jul 1

PMID 1630306

Citations 665

Authors

K Tamura

Affiliations

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Abstract

A simple mathematical method is developed to estimate the number of nucleotide substitutions per site between two DNA sequences, by extending Kimura's (1980) two-parameter method to the case where a G+C-content bias exists. This method will be useful when there are strong transition-transversion and G+C-content biases, as in the case of Drosophila mitochondrial DNA.

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