High Performance Liquid Chromatography/electrospray Ionization Mass Spectrometry for Simultaneous Analysis of Alkamides and Caffeic Acid Derivatives from Echinacea Purpurea Extracts

Overview

Journal J Chromatogr A

Publisher Elsevier

Specialty Chemistry

Date 2005 Nov 22

PMID 16298376

Citations 17

Authors

Nadja B Cech

Maqueita S Eleazer

Lawresa T Shoffner

Mark R Crosswhite

Amanda C Davis

Ashley M Mortenson

Affiliations

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Abstract

Extracts of the plant Echinacea purpurea are widely used for medicinal purposes. Effective quality control of these extracts requires rapid methods to determine their chemical composition. A new method for analysis of caffeic acid derivatives and alkamides from Echinacea extracts has been developed. With this method, isomeric isobutylamides and 2-methylbutylamides can be distinguished, a capability that previously published methods have lacked. Quantitative analyses carried out with this method on E. purpurea extracts that have been stored for 18 months indicate that they contain caftaric acid, cichoric acid, and undeca-2Z,4E-diene-8,10-diynoic acid isobutylamide at concentrations of 0.7, 0.71 and 2.0mg/mL, respectively.

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