Cytotoxic Activity of Intestinal Lamina Propria Lymphocytes on Human Immunodeficiency Virus (HIV)-infected Cells

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1992 May 1

PMID 1628889

Citations 2

Authors

A M Di Massimo

R Placido

S Bach

A M Anastasi

A Mastino

M R Capobianchi

V Colizzi

Affiliations

Soon will be listed here.

Abstract

The phenotype and cytotoxic activity of lamina propria lymphocytes (LPL) from the colorectal mucosa have been investigated primarily to analyse the role of LPL in human immunodeficiency virus (HIV) infection. The results reported here show that LPL strictly required a proliferative stimulus [either interleukin-2 (IL-2) or phytohaemaglutinin (PHA) to develop strong in vitro cytotoxicity, since freshly isolated LPL do not exhert cytotoxicity against either natural killer (NK)-sensitive or NK-resistant target cells. The cytotoxicity of activated LPL against a large panel of myeloid tumours or colorectal carcinoma target cells shows the irrelevance of the tissue origin of target cells. Moreover, activated LPL lysed HIV-infected H9 cells more efficiently than peripheral blood lymphocytes (PBL), and were susceptible to HIV infection. In contrast, unstimulated LPL failed to be cytotoxic and susceptible to HIV. Thus, we strongly suggest that for the lymphocytes of the colorectal mucosa expression of cytotoxic activity and susceptibility to HIV-infection show two faces of the same coin, and therefore may be relevant in understanding the mechanisms and paths of transmission of HIV infection.

Citing Articles

Mucosal macrophage subsets of the gut in HIV: decrease in antigen-presenting cell phenotype.

Lim S, Condez A, Poulter L Clin Exp Immunol. 1993; 92(3):442-7.

PMID: 8513576 PMC: 1554780. DOI: 10.1111/j.1365-2249.1993.tb03418.x.

Cytotoxic activity of human lymphocytes against differentiated intestinal tumour cell lines.

Anelli R, Placido R, Sambuy Y, Bach S, Di Massimo A, Colizzi V Immunology. 1993; 78(1):166-9.

PMID: 8436403 PMC: 1421771.

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